Ventricular arterial coupling and cardiovascular risk among young adults: The African-PREDICT study - Université de Lorraine Access content directly
Journal Articles AJP - Heart and Circulatory Physiology Year : 2023

Ventricular arterial coupling and cardiovascular risk among young adults: The African-PREDICT study

Abstract

Aims: Studies exploring ventricular-arterial coupling (VAC) parameters and their association with anthropometric and cardiovascular (CV) factors are sparse in young asymptomatic individuals. Here, we aim to provide in an asymptomatic group of young participants, descriptive data regarding VAC and to explore its associations with CV risk factors. Methods: For 631 (mean age 24±3 years; 51% female) individuals participating in the African-PREDICT cohort, VAC was determined by pulse wave velocity (PWV)/global longitudinal strain (GLS). Multivariable logistic and linear regression models were performed to explore the association between PWV/GLS and CV risk factors. Results: The mean value of PWV/GLS was 0.33±0.07 m/s %. Higher ratios of PWV/GLS were associated with older age, male sex and a higher prevalence of CV risk factors (i.e., higher blood pressure and hypertension, increased waist circumference, active smoking, higher plasma triglycerides, lower high-density lipoprotein cholesterol and an adverse urine albumin/creatinine ratio). Further, higher PWV/GLS was associated with echocardiographic measures such as decreased ejection fraction and increased left ventricle mass index. In fully adjusted logistic regression models, higher ratios of PWV/GLS were significantly associated with the prevalence of active smoking (OR 1.88; CI 1.36 - 2.58, p<0.001) and hypertension (OR 1.98; CI 1.40 - 2.80, p<0.001). Conclusions: We demonstrated that VAC mismatch reflected by higher values of PWV/GLS are significantly associated with CV risk factors in young adults. The results suggest that PWV/GLS might serve as a tool to improve the profiling of cardiovascular risk in young adults.
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Dates and versions

hal-04150964 , version 1 (04-07-2023)

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Hannes Holm, Ruan Kruger, Amra Jujic, Zohra Lamiral, Aletta Sophia Uys, et al.. Ventricular arterial coupling and cardiovascular risk among young adults: The African-PREDICT study. AJP - Heart and Circulatory Physiology, 2023, ⟨10.1152/ajpheart.00179.2023⟩. ⟨hal-04150964⟩
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