Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial

Silvio Danese; Severine Vermeire; Geert d'Haens; Julian Panés; Axel Dignass; Fernando Magro; Maciej Nazar; Manuela Le Bars; Marjolein Lahaye; Lioudmila Ni; Ivana Bravata; Frederic Lavie; Marco Daperno; Milan Lukáš; Alessandro Armuzzi; Mark Löwenberg; Daniel Gaya; Laurent Peyrin‐biroulet; Rodolfo Rocca; Susana Lopes; Flavio Caprioli; Sandro Ardizzone; Ana Echarri Piudo; Paolo Gionchetti; Xavier Roblin; Ursula Seidler; David Andersson; Kamal Patel; Pierre Desreumaux; Simone Saibeni; Gustav From; Miroslav Fedurco; Milos Gregus; Yoram Bouhnik; Andreas Luegering; Rocco Cosintino; Ivan Bunganic; Jaime Ramos; Mariam Aguas Peris; Olivier Dewit; Mariabeatrice Principi; Emma Wesley; Paula Lago; Stephane Nancey; María Dolores Martín Arranz; Pieter Hindryckx; Ambrogio Orlando; Andrea Geccherle; Maria Laura Annunziata; Bu'Hussain Hayee; Jozef Balaz; Francisco Portela; Cyrielle Gilletta; Torsten Kucharzik; Miguel Mínguez; Javier Pérez Gisbert; Ana Gutiérrez Casbas; Edouard Louis; Marco Marino; Gareth Parkes; Fraser Cummings; Bindia Jharap; Jens Kjeldsen; Luís Correia; Paula Ministro; Matthias Ebert; Erik Hertervig; Dirk Staessen; Joris Dutré; Arnaud Colard; Graham Morrison; Henning Glerup; Jens Frederik Dahlerup; Frank Wolfhagen; Marian Batovsky; Martin Molnar; Barbora Kadleckova; Paulo Caldeira; David Laharie; Xavier Hebuterne; Bruno Bonaz; Matthieu Allez; Andreas Fischer; Joaquín Ernesto Hinojosa del Val; Miriam Mañosa Ciria; Jose Manuel Herrera Justiniano; Charlotte Soderman; Rajiv Chandy; Craig Mowat; Peter Irving; Jan Fallingborg; Jan Matous; Tomas Douda; Romain Altwegg; Jose Manuel Benitez; María Teresa Arroyo Villarino; Jordi Guardiola Capón; Daniel Ginard Vicenc; Pieter Dewint; Sven Almer; Sebastien Kindt

doi:10.1016/S2468-1253(21)00474-X

Journal Articles The Lancet Gastroenterology & Hepatology Year : 2022

Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial

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Silvio Danese

Function : Author

IRCCS Ospedale San Raffaele [Milan, Italy]

Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]

Severine Vermeire

Function : Author

University Hospitals Leuven [Leuven]

Geert d'Haens

Function : Author

University of Amsterdam [Amsterdam] = Universiteit van Amsterdam

Julian Panés

Function : Author

Clinic Barcelona Hospital Universitari

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas

Axel Dignass

Function : Author

Agaplesion Markus Krankenhaus = Agaplesion Markus Hospital [Frankfurt]

Fernando Magro

Function : Author

Instituto de Biologia Molecular e Celular - institute for molecular and cell biology [Porto, Portugal]

Maciej Nazar

Function : Author

Manuela Le Bars

Function : Author

Janssen-Cilag [Issy-les-Moulineaux]

Marjolein Lahaye

Function : Author

Lioudmila Ni

Function : Author

Ivana Bravata

Function : Author

Frederic Lavie

Function : Author

Janssen-Cilag [Issy-les-Moulineaux]

Marco Daperno

Function : Author

Mauriziano Umberto Hospital [Turin, Italy]

Milan Lukáš

Function : Author

Alessandro Armuzzi

Function : Author

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]

Mark Löwenberg

Function : Author

University of Amsterdam [Amsterdam] = Universiteit van Amsterdam

Daniel Gaya

Function : Author

Glasgow Royal Infirmary

Laurent Peyrin‐biroulet

Function : Author
PersonId : 1111110
ORCID : 0000-0003-2536-6618
IdRef : 087640147

Nutrition-Génétique et Exposition aux Risques Environnementaux

Service d'Hépato-gastro-entérologie [CHRU Nancy]

Rodolfo Rocca

Function : Author

Susana Lopes

Function : Author

Flavio Caprioli

Function : Author

Sandro Ardizzone

Function : Author

Ana Echarri Piudo

Function : Author

Paolo Gionchetti

Function : Author

Xavier Roblin

Function : Author

Ursula Seidler

Function : Author

David Andersson

Function : Author

Kamal Patel

Function : Author

Pierre Desreumaux

Function : Author

Simone Saibeni

Function : Author

Gustav From

Function : Author

Miroslav Fedurco

Function : Author

Milos Gregus

Function : Author

Yoram Bouhnik

Function : Author
PersonId : 1225458
ORCID : 0000-0002-5787-4943
IdRef : 059203587

Andreas Luegering

Function : Author

Rocco Cosintino

Function : Author

Ivan Bunganic

Function : Author

Jaime Ramos

Function : Author

Mariam Aguas Peris

Function : Author

Olivier Dewit

Function : Author

Mariabeatrice Principi

Function : Author

Emma Wesley

Function : Author

Paula Lago

Function : Author

Stephane Nancey

Function : Author
PersonId : 928425
ORCID : 0000-0003-2088-1442

María Dolores Martín Arranz

Function : Author

Pieter Hindryckx

Function : Author

Ambrogio Orlando

Function : Author

Andrea Geccherle

Function : Author

Maria Laura Annunziata

Function : Author

Bu'Hussain Hayee

Function : Author

Jozef Balaz

Function : Author

Francisco Portela

Function : Author

Cyrielle Gilletta

Function : Author

Torsten Kucharzik

Function : Author

Miguel Mínguez

Function : Author

Javier Pérez Gisbert

Function : Author

Ana Gutiérrez Casbas

Function : Author

Edouard Louis

Function : Author

Marco Marino

Function : Author

Gareth Parkes

Function : Author

Fraser Cummings

Function : Author

Bindia Jharap

Function : Author

Jens Kjeldsen

Function : Author

Luís Correia

Function : Author

Paula Ministro

Function : Author

Matthias Ebert

Function : Author

Erik Hertervig

Function : Author

Dirk Staessen

Function : Author

Joris Dutré

Function : Author

Arnaud Colard

Function : Author

Graham Morrison

Function : Author

Henning Glerup

Function : Author

Jens Frederik Dahlerup

Function : Author

Frank Wolfhagen

Function : Author

Marian Batovsky

Function : Author

Martin Molnar

Function : Author

Barbora Kadleckova

Function : Author

Paulo Caldeira

Function : Author

David Laharie

Function : Author

Xavier Hebuterne

Function : Author

Bruno Bonaz

Function : Author
PersonId : 859832
ORCID : 0000-0003-1858-8941
IdRef : 067137946

Matthieu Allez

Function : Author

Andreas Fischer

Function : Author

Joaquín Ernesto Hinojosa del Val

Function : Author

Miriam Mañosa Ciria

Function : Author

Jose Manuel Herrera Justiniano

Function : Author

Charlotte Soderman

Function : Author

Rajiv Chandy

Function : Author

Craig Mowat

Function : Author

Peter Irving

Function : Author

Jan Fallingborg

Function : Author

Jan Matous

Function : Author

Tomas Douda

Function : Author

Romain Altwegg

Function : Author

Jose Manuel Benitez

Function : Author

María Teresa Arroyo Villarino

Function : Author

Jordi Guardiola Capón

Function : Author

Daniel Ginard Vicenc

Function : Author

Pieter Dewint

Function : Author

Sven Almer

Function : Author

Sebastien Kindt

Function : Author

Abstract

A treat-to-target strategy, in which strictly defined treatment targets facilitate decision making in clinical practice, is advocated as an optimised management approach for some chronic disorders. The aim of the STARDUST trial was to assess whether a treat-to-target strategy with early endoscopy, regular biomarker and clinical symptom monitoring, and dose intensification for persistent inflammatory activity, was more successful in achieving endoscopic improvement at week 48 than a clinically driven maintenance strategy in patients with moderate-to-severe active Crohn's disease receiving ustekinumab.

Janssen-Cilag.

Domains

Life Sciences [q-bio]

Benjamin GROSJEAN : Connect in order to contact the contributor

https://hal.univ-lorraine.fr/hal-04165822

Submitted on : Wednesday, July 19, 2023-12:42:17 PM

Last modification on : Friday, October 4, 2024-1:54:03 PM

Dates and versions

hal-04165822 , version 1 (19-07-2023)

Identifiers

HAL Id : hal-04165822 , version 1
DOI : 10.1016/S2468-1253(21)00474-X
PUBMED : 35120656

Cite

Silvio Danese, Severine Vermeire, Geert d'Haens, Julian Panés, Axel Dignass, et al.. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial. The Lancet Gastroenterology & Hepatology, 2022, 7 (4), pp.294-306. ⟨10.1016/S2468-1253(21)00474-X⟩. ⟨hal-04165822⟩

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Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial

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