IOIBD Recommendations for Clinical Trials in Ulcerative Proctitis: The PROCTRIAL Consensus
Bénédicte Caron
(1, 2)
,
Maria Abreu
(3)
,
Corey Siegel
(4)
,
Remo Panaccione
(5)
,
Bruce Sands
,
Axel Dignass
(6)
,
Dan Turner
(7)
,
Iris Dotan
(8)
,
Ailsa Hart
(9)
,
Vineet Ahuja
(10)
,
Matthieu Allez
(11, 12)
,
Ashwin Ananthakrishnan
(13, 14)
,
Subrata Ghosh
(15)
,
Anne Griffiths
(16, 17)
,
Jonas Halfvarson
(18)
,
Arthur Kaser
(19, 20)
,
Paulo Kotze
(21)
,
Ioannis Koutroubakis
(22)
,
Peter Lakatos
(23)
,
Arie Levine
(24)
,
James Lewis
(25)
,
Fernando Magro
(26)
,
Gerassimos Mantzaris
(27)
,
Colm O'Morain
(28)
,
Zhihua Ran
(29)
,
Walter Reinisch
(30)
,
Gerhard Rogler
(31)
,
David Sachar
(32)
,
Britta Siegmund
(33)
,
Mark Silverberg
(34)
,
Ajit Sood
(35)
,
Antonino Spinelli
(36)
,
Flavio Steinwurz
(37)
,
Curt Tysk
(18)
,
Jesus Yamamoto-Furusho
(38)
,
Stefan Schreiber
(39)
,
David Rubin
(40)
,
William Sandborn
(41)
,
Silvio Danese
(42)
,
Laurent Peyrin‐biroulet
(1, 2)
1
NGERE -
Nutrition-Génétique et Exposition aux Risques Environnementaux
2 Service d'Hépato-gastro-entérologie [CHRU Nancy]
3 UMMSM - University of Miami Leonard M. Miller School of Medicine
4 DHMC - Dartmouth Hitchcock Medical Center
5 University of Calgary
6 Goethe-Universität Frankfurt am Main
7 HUJ - The Hebrew University of Jerusalem
8 Sackler Faculty of Medicine
9 NPH - Northwick Park Hospital [Harrow, UK]
10 All India Institute of Medical Sciences [New Delhi]
11 EMily (UMR_S_1160 / U1160) - Ecotaxie, microenvironnement et développement lymphocytaire
12 AP-HP - Hopital Saint-Louis [AP-HP]
13 Massachusetts General Hospital [Boston]
14 HMS - Harvard Medical School [Boston]
15 UCC - University College Cork
16 SickKids - The Hospital for sick children [Toronto]
17 University of Toronto
18 Örebro University
19 CAM - University of Cambridge [UK]
20 CUH - Cambridge University Hospitals - NHS
21 PUCPR - Pontifícia Universidade Católica do Paraná [Curitiba, Brasil] = Pontifical Catholic University of Paraná [Curitiba, Brazil] = Université catholique pontificale du Paraná [Curitiba, Brésil]
22 UOC - University of Crete [Heraklion]
23 MUHC - McGill University Health Center [Montreal]
24 Wolfson Medical Center
25 Perelman School of Medicine
26 Universidade do Porto = University of Porto
27 Evangelismos Athens General Hospital
28 Trinity College Dublin
29 Shanghai Jiao Tong University School of Medicine
30 Medizinische Universität Wien = Medical University of Vienna
31 University hospital of Zurich [Zurich]
32 MSSM - Icahn School of Medicine at Mount Sinai [New York]
33 Charité - UniversitätsMedizin = Berlin University Medicine
34 MSH - Mount Sinai Hospital [Toronto, Canada]
35 Dayanand Medical College and Hospital [Ludhiana]
36 Hunimed - Humanitas University [Milan]
37 Hospital Israelita Albert Einstein [São Paulo, Brazil]
38 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico]
39 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
40 The University of Chicago Medicine [Chicago]
41 UC San Diego - University of California [San Diego]
42 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
2 Service d'Hépato-gastro-entérologie [CHRU Nancy]
3 UMMSM - University of Miami Leonard M. Miller School of Medicine
4 DHMC - Dartmouth Hitchcock Medical Center
5 University of Calgary
6 Goethe-Universität Frankfurt am Main
7 HUJ - The Hebrew University of Jerusalem
8 Sackler Faculty of Medicine
9 NPH - Northwick Park Hospital [Harrow, UK]
10 All India Institute of Medical Sciences [New Delhi]
11 EMily (UMR_S_1160 / U1160) - Ecotaxie, microenvironnement et développement lymphocytaire
12 AP-HP - Hopital Saint-Louis [AP-HP]
13 Massachusetts General Hospital [Boston]
14 HMS - Harvard Medical School [Boston]
15 UCC - University College Cork
16 SickKids - The Hospital for sick children [Toronto]
17 University of Toronto
18 Örebro University
19 CAM - University of Cambridge [UK]
20 CUH - Cambridge University Hospitals - NHS
21 PUCPR - Pontifícia Universidade Católica do Paraná [Curitiba, Brasil] = Pontifical Catholic University of Paraná [Curitiba, Brazil] = Université catholique pontificale du Paraná [Curitiba, Brésil]
22 UOC - University of Crete [Heraklion]
23 MUHC - McGill University Health Center [Montreal]
24 Wolfson Medical Center
25 Perelman School of Medicine
26 Universidade do Porto = University of Porto
27 Evangelismos Athens General Hospital
28 Trinity College Dublin
29 Shanghai Jiao Tong University School of Medicine
30 Medizinische Universität Wien = Medical University of Vienna
31 University hospital of Zurich [Zurich]
32 MSSM - Icahn School of Medicine at Mount Sinai [New York]
33 Charité - UniversitätsMedizin = Berlin University Medicine
34 MSH - Mount Sinai Hospital [Toronto, Canada]
35 Dayanand Medical College and Hospital [Ludhiana]
36 Hunimed - Humanitas University [Milan]
37 Hospital Israelita Albert Einstein [São Paulo, Brazil]
38 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico]
39 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
40 The University of Chicago Medicine [Chicago]
41 UC San Diego - University of California [San Diego]
42 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
Bruce Sands
- Fonction : Auteur
Laurent Peyrin‐biroulet
- Fonction : Auteur
- PersonId : 1111110
- ORCID : 0000-0003-2536-6618
- IdRef : 087640147
Résumé
Clinical trials evaluating biologics and small molecules in patients with ulcerative colitis are predominantly excluding ulcerative proctitis. The objective of the Definition and endpoints for ulcerative PROCtitis in clinical TRIALs initiative was to develop consensus statements for definitions, inclusion criteria, and endpoints for the evaluation of ulcerative proctitis in adults.