Subclinical Persistent Inflammation as Risk Factor for Crohn's Disease Progression: Findings From a Prospective Real-World Study of 2 Years
Fernando Magro
(1, 2)
,
Diogo Magalhães
(1)
,
Marta Patita
(3)
,
Bruno Arroja
,
Paula Lago
(4)
,
Isadora Rosa
,
Helena Tavares de Sousa
(5)
,
Paula Ministro
(6)
,
Irinia Mocanu
(3)
,
Ana Vieira
(3)
,
Joana Castela
,
Joana Moleiro
,
Joana Roseira
,
Eugénia Cancela
(6)
,
Paula Sousa
(6)
,
Francisco Portela
(7)
,
Luís Correia
,
Mafalda Santiago
,
Sandra Dias
,
Catarina Alves
(1)
,
Joana Afonso
(1)
,
Silvio Danese
(8, 9)
,
Laurent Peyrin‐biroulet
(10, 11)
,
Claudia Camila Dias
(1)
1
Universidade do Porto = University of Porto
2 Hospital de São João [Porto]
3 EPE - Hospital Garcia de Orta
4 Centro Hospitalar do Porto
5 UAlg - Universidade do Algarve
6 CHTV - Centro Hospitalar Tondela-Viseu [Viseu, Portugal]
7 Centro Hospitalar e Universitário [Coimbra]
8 Hunimed - Humanitas University [Milan]
9 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
10 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
11 Service d'Hépato-gastro-entérologie [CHRU Nancy]
2 Hospital de São João [Porto]
3 EPE - Hospital Garcia de Orta
4 Centro Hospitalar do Porto
5 UAlg - Universidade do Algarve
6 CHTV - Centro Hospitalar Tondela-Viseu [Viseu, Portugal]
7 Centro Hospitalar e Universitário [Coimbra]
8 Hunimed - Humanitas University [Milan]
9 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
10 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
11 Service d'Hépato-gastro-entérologie [CHRU Nancy]
Fernando Magro
- Function : Author
- PersonId : 1271303
- ORCID : 0000-0003-2634-9668
Bruno Arroja
- Function : Author
Isadora Rosa
- Function : Author
Joana Castela
- Function : Author
Joana Moleiro
- Function : Author
Joana Roseira
- Function : Author
Luís Correia
- Function : Author
Mafalda Santiago
- Function : Author
Sandra Dias
- Function : Author
Laurent Peyrin‐biroulet
- Function : Author
- PersonId : 1111110
- ORCID : 0000-0003-2536-6618
- IdRef : 087640147
Abstract
Subclinical intestinal inflammation is common in Crohn's disease (CD). We aimed to explore its impact in the disease progression of infliximab-treated patients and the usefulness of fecal calprotectin (FC) and C-reactive protein (CRP) as surrogate minimally invasive biomarkers.