Layer myocardial strain is the most heritable echocardiographic trait - Université de Lorraine Access content directly
Journal Articles European Heart Journal - Cardiovascular Imaging Year : 2023

Layer myocardial strain is the most heritable echocardiographic trait


Abstract Aims Myocardial deformation assessed by strain analysis represents a significant advancement in our assessment of cardiac mechanics. However, whether this variable is genetically heritable or whether all/most of its variability is related to environmental factors is currently unknown. We sought to determine the heritability of echocardiographically determined cardiac mechanics indices in a population setting. Methods and results A total of 1357 initially healthy subjects (women 51.6%; 48.2 ± 14.1 years) were included in this study from 20-year follow-up after the fourth visit of the longitudinal familial STANISLAS cohort (Lorraine, France). Data were acquired using state-of-the-art cardiac ultrasound equipment, using acquisition and measurement protocols recommended by the EACVI (European Association of Cardiovascular Imaging)/ASE (American Society of Echocardiography)/Industry Task Force. Layer-specific global longitudinal strain (GLS) and global circumferential strain (full-wall, subendocardial, and subepicardial) and conventional structural and functional cardiac parameters and their potential heritability were assessed using restricted maximum likelihood analysis, with genetic relatedness matrix calculated from genome-wide association data. Indices of longitudinal/circumferential myocardial function and left ventricular (LV) ejection fraction had low heritability (ranging from 10% to 20%). Diastolic and standard LV function parameters had moderate heritability (ranging from 20% to 30%) except for end-systolic and end-diastolic volumes (30% and 45%, respectively). In contrast, global longitudinal subendocardial strain (GLSEndo)/global longitudinal subepicardial strain (GLSEpi) ratio had a high level of heritability (65%). Except for GLSEndo/GLSEpi ratio, a large percentage of variance remained unexplained (>50%). Conclusions In our population cohort, GLSEndo/GLSEpi ratio had a high level of heritability, whereas other classical and mechanical LV function parameters did not. Given the increasing recognition of GLSEndo/GLSEpi ratio as an early/sensitive imaging biomarker of systolic dysfunction, our results suggest the possible existence of individual genetic predispositions to myocardial decline.
Fichier principal
Vignette du fichier
manuscrit.pdf (867.06 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-04192912 , version 1 (31-08-2023)



Olivier Huttin, Constance Xhaard, Claire Dandine-Roulland, Edith Le Floch, Delphine Bacq-Daian, et al.. Layer myocardial strain is the most heritable echocardiographic trait. European Heart Journal - Cardiovascular Imaging, 2023, 24 (10), pp.1394-1403. ⟨10.1093/ehjci/jead146⟩. ⟨hal-04192912⟩
37 View
34 Download



Gmail Mastodon Facebook X LinkedIn More