Determinants of IBD‐related disability: a cross‐sectional survey from the GETAID
Jenny Tannoury
(1, 2)
,
Maria Nachury
(3, 4)
,
Carole Martins
(5, 6)
,
Melanie Serrero
(7, 8, 9)
,
Jerome Filippi
(10, 11)
,
Xavier Roblin
(12)
,
Anne Bourrier
(13)
,
Guillaume Bouguen
(14, 15, 16)
,
Denis Franchimont
(17)
,
Guillaume Savoye
(18)
,
Anthony Buisson
(19, 20)
,
Edouard Louis
(21)
,
Stephane Nancey
(22, 23)
,
Vered Abitbol
(24)
,
Jean-Marie Reimund
(25, 26, 27, 28)
,
Olivier Dewitt
(29)
,
Lucine Vuitton
(30)
,
Nicolas Mathieu
(31)
,
Laurent Peyrin-Biroulet
(32, 33)
,
Cyrielle Gilletta
(34)
,
Matthieu Allez
(35)
,
Stephanie Viennot
(36)
,
Caroline Trang-Poisson
(37)
,
David Laharie
(38)
,
Aurelien Amiot
(1, 2)
,
Jean‐marie Reimund
(25, 26, 27, 28)
1
Service de gastro-entérologie [Henri Mondor AP-HP, Créteil]
2 EC2M3 - Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375)
3 Hôpital Claude Huriez [Lille]
4 Université de Lille
5 Service de Gastroentérologie [Hôpital Beaujon]
6 UPD7 - Université Paris Diderot - Paris 7
7 CIC - Centre d’Investigation Clinique Marseille Nord
8 Hôpital Nord [CHU - APHM]
9 AMU - Aix Marseille Université
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 UniCA - Université Côte d'Azur
12 Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne]
13 CHU Saint-Antoine [AP-HP]
14 Service d'hépato-gastro-entérologie [Rennes] = Gastroenterology [Rennes]
15 CIC - Centre d'Investigation Clinique [Rennes]
16 NuMeCan - Nutrition, Métabolismes et Cancer
17 HUB-ULB - Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis
18 Service d'Hépato-Gastroentérologie [CHU Rouen]
19 CHU Estaing [Clermont-Ferrand]
20 UCA - Université Clermont Auvergne
21 CHU-Liège - Centre Hospitalier Universitaire de Liège
22 HCL - Hospices Civils de Lyon
23 CIRI - Centre International de Recherche en Infectiologie
24 Service de Gastro-entérologie [CHU Cochin]
25 Hôpital de Hautepierre [Strasbourg]
26 IHU Strasbourg - L'Institut hospitalo-universitaire de Strasbourg
27 IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
28 FHU ARRIMAGE - Fédération Hospitalo-Universitaire "Digestive and OsteoARticular Remodeling/Inflammation/Immunomodulation/Metabolism in diseased ACEing"
29 Cliniques Universitaires Saint-Luc [Bruxelles]
30 Service de Gastro-Entérologie [CHRU Besançon]
31 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
32 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
33 Service d'Hépato-gastro-entérologie [CHRU Nancy]
34 Service de Gastroentérologie et pancréatologie [CHU Toulouse]
35 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
36 Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
37 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
38 Hôpital Haut-Lévêque [CHU Bordeaux]
2 EC2M3 - Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375)
3 Hôpital Claude Huriez [Lille]
4 Université de Lille
5 Service de Gastroentérologie [Hôpital Beaujon]
6 UPD7 - Université Paris Diderot - Paris 7
7 CIC - Centre d’Investigation Clinique Marseille Nord
8 Hôpital Nord [CHU - APHM]
9 AMU - Aix Marseille Université
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 UniCA - Université Côte d'Azur
12 Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne]
13 CHU Saint-Antoine [AP-HP]
14 Service d'hépato-gastro-entérologie [Rennes] = Gastroenterology [Rennes]
15 CIC - Centre d'Investigation Clinique [Rennes]
16 NuMeCan - Nutrition, Métabolismes et Cancer
17 HUB-ULB - Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis
18 Service d'Hépato-Gastroentérologie [CHU Rouen]
19 CHU Estaing [Clermont-Ferrand]
20 UCA - Université Clermont Auvergne
21 CHU-Liège - Centre Hospitalier Universitaire de Liège
22 HCL - Hospices Civils de Lyon
23 CIRI - Centre International de Recherche en Infectiologie
24 Service de Gastro-entérologie [CHU Cochin]
25 Hôpital de Hautepierre [Strasbourg]
26 IHU Strasbourg - L'Institut hospitalo-universitaire de Strasbourg
27 IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
28 FHU ARRIMAGE - Fédération Hospitalo-Universitaire "Digestive and OsteoARticular Remodeling/Inflammation/Immunomodulation/Metabolism in diseased ACEing"
29 Cliniques Universitaires Saint-Luc [Bruxelles]
30 Service de Gastro-Entérologie [CHRU Besançon]
31 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
32 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
33 Service d'Hépato-gastro-entérologie [CHRU Nancy]
34 Service de Gastroentérologie et pancréatologie [CHU Toulouse]
35 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
36 Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
37 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
38 Hôpital Haut-Lévêque [CHU Bordeaux]
Jenny Tannoury
- Function : Author
- PersonId : 1335783
- ORCID : 0000-0001-6439-1782
Xavier Roblin
- Function : Author
- PersonId : 886939
- ORCID : 0000-0002-7929-4878
Guillaume Bouguen
- Function : Author
- PersonId : 783033
- ORCID : 0000-0002-7444-5905
- IdRef : 129420271
Anthony Buisson
- Function : Author
- PersonId : 763185
- ORCID : 0000-0002-6347-409X
- IdRef : 167502484
Stephane Nancey
- Function : Author
- PersonId : 928425
- ORCID : 0000-0003-2088-1442
Jean-Marie Reimund
- Function : Author
Laurent Peyrin-Biroulet
- Function : Author
- PersonId : 1111110
- ORCID : 0000-0003-2536-6618
- IdRef : 087640147
Matthieu Allez
- Function : Author
- PersonId : 762385
- ORCID : 0000-0002-2012-7522
- IdRef : 050201581
Caroline Trang-Poisson
- Function : Author
- PersonId : 1229326
- ORCID : 0000-0001-9140-5844
David Laharie
- Function : Author
- PersonId : 1209275
- ORCID : 0000-0002-4753-6676
Aurelien Amiot
- Function : Author
- PersonId : 1010648
- ORCID : 0000-0001-6676-1222
Jean‐marie Reimund
- Function : Author
Abstract
Background - The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability. Aims - To identify the predictive factors of disability in a large population of patients with IBD. Patients and methods - We conducted a cross-sectional survey in 42 tertiary centres in France and Belgium. A self-administered questionnaire was designed to explore patients and their IBD characteristics. IBD-disk is a validated tool to measure disability in patients with IBD. The IBD-disk score was then calculated for each patient. Based on a previous study, an overall IBD-disk score ≥40 was associated with moderate-to-severe disability. Results - Among the 2011 patients, 1700 were analysed, including 746 (44%) in self-reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate-to-severe disability was significantly increased in patients with BMI >25 kg/m (OR = 1.66; 95% CI [1.29-2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79-3.05]) and social worker (OR = 1.54; 95% CI [1.08-2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69-0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53-0.92]), self-reported clinical remission (OR = 0.59; 95% CI [0.46-0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52-0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability. Conclusion - Determinants of IBD-related disability include IBD-related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.