Impact of a public commitment charter, a non-prescription pad and an antibiotic information leaflet to improve antibiotic prescription among General Practitioners: a randomised controlled study - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Journal of Infection and Public Health Année : 2024

Impact of a public commitment charter, a non-prescription pad and an antibiotic information leaflet to improve antibiotic prescription among General Practitioners: a randomised controlled study

Résumé

Background: This study evaluated the effect of a multifaceted antibiotic stewardship intervention on the overall prescription of systemic antibiotics in primary care. Secondary objectives evaluated the effect on the prescription of broad-spectrum antibiotics and the seasonal variation of both total antibiotic and quinolone prescriptions, as a proxy for unnecessary prescribing. Methods: This pragmatic, randomised, controlled, before-after intervention study was conducted among general practitioners (GPs) who over prescribe antibiotics in Lorraine, France (Intervention group, n=109; Control group, n=236; Before period, 01/10/2017-30/09/2018; After period, 01/10/2018-30/09/2019). The intervention included a public commitment charter, a patient information leaflet and a non-prescription pad. Health Insurance data was obtained to calculate overall and broad-spectrum prescription rate (defined daily doses/1000 consultations) and the seasonal variation of prescriptions (%), by period. The intervention effect was measured with general linear mixed models including three independent variables (group, period and group x period interaction). Results: Overall, compared to the Before period, GPs in both groups prescribed significantly fewer systemic antibiotics (p<0.001) and broad-spectrum antibiotics (p<0.001) after the intervention was implemented. However, the group x period interaction did not show any evidence that the intervention had an effect on these outcomes. Nevertheless, the intervention did result in a trend towards less seasonal variation in total systemic antibiotic prescription (p=0.052). Conclusions: A tendency towards an effect of the intervention to reduce unnecessary antibiotic prescribing during winter months was observed. No effect was observed on the overall volume of systemic antibiotic prescription. This study invites discussion about the challenges faced when evaluating non-pharmacological interventions in primary care.
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Dates et versions

hal-04352438 , version 1 (19-12-2023)

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Aurélie Bocquier, Anaïs Essilini, Ouarda Pereira, Adeline Welter, Céline Pulcini, et al.. Impact of a public commitment charter, a non-prescription pad and an antibiotic information leaflet to improve antibiotic prescription among General Practitioners: a randomised controlled study. Journal of Infection and Public Health, 2024, 17 (2), pp.217-225. ⟨10.1016/j.jiph.2023.11.027⟩. ⟨hal-04352438⟩
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