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Article Dans Une Revue JACC: Heart Failure Année : 2024

Efficacy and Safety of Empagliflozin According to Background Diuretic Use in HFrEF

Naveed Sattar

Résumé

BACKGROUND The EMPEROR-Reduced (EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction) trial established the efficacy of empagliflozin in reducing heart failure (HF) outcomes among patients with heart failure with reduced ejection fraction (HFrEF). OBJECTIVES The authors examined the outcomes of EMPEROR-Reduced as a function of background diuretic therapy. METHODS The EMPEROR-Reduced trial was a double-blind, randomized controlled trial of placebo vs empagliflozin 10 mg among 3,730 HFrEF patients. Herein, the population was stratified into 4 groups: no diuretic and diuretic dose equivalent to furosemide <40, 40, and >40 mg daily at baseline. RESULTS A total of 3,656 patients from the EMPEROR-Reduced trial were available for analysis. Of those patients, 482 (13.2%) were receiving no diuretic therapy, and 731 (20.0%), 1,411 (38.6%), and 1,032 (28.2%) were receiving <40 mg, 40 mg, and >40 mg, respectively. The efficacy of empagliflozin on the primary outcome (time to first event of hospitalization for HF or cardiovascular [CV] death) was consistent regardless of background diuretic therapy (>40
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hal-04384319 , version 1 (10-01-2024)

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Nitish K Dhingra, Subodh Verma, Javed Butler, Stefan D Anker, Joao Pedro Ferreira, et al.. Efficacy and Safety of Empagliflozin According to Background Diuretic Use in HFrEF. JACC: Heart Failure, 2024, 12 (1), pp.35-46. ⟨10.1016/j.jchf.2023.06.036⟩. ⟨hal-04384319⟩
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