Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Cardiovascular Diabetology Année : 2024

Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial

Résumé

Abstract Background Diabetic cardiomyopathy (DbCM) is a form of Stage B heart failure (HF) at high risk for progression to overt disease. Using baseline characteristics of study participants from the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure (ARISE-HF) Trial we sought to characterize clinical characteristics of individuals with findings consistent with DbCM. Methods Among study participants meeting inclusion criteria, clinical characteristics, laboratory testing, imaging, Kansas City Cardiomyopathy Questionnaire (KCCQ), Physical Activity Scale of the Elderly (PASE) and cardiopulmonary exercise testing (CPET) results were tabulated. Cluster phenogroups were identified. Results Among 691 study participants (mean age 67.4 years; 50% were female), mean duration of type 2 diabetes mellitus (T2DM) was 14.5 years. The median (Q1, Q3) N-terminal pro-B type natriuretic peptide and high sensitivity cardiac troponin T were 71 (35, 135) ng/L and 9 [6, 12] ng/L. The most common echocardiographic abnormalities were reduced global longitudinal strain in 25.3% and impaired diastolic relaxation in 17.7%. Despite rather well-preserved KCCQ scores the average PASE score was markedly impaired at 155 accompanied by an average maximal oxygen consumption of 15.7 mL/Kg/minute on CPET. In K-means clustering, 4 phenogroups were identified including a higher-risk group with more advanced age, greater elevation of cardiac biomarkers, and more prevalent evidence for diastolic dysfunction and left ventricular hypertrophy. Conclusions Baseline data from the ARISE-HF Trial provide clinical characterization of individuals with T2DM and features of stage B HF, and may help clarify the diagnosis of DbCM. Trial Registration ARISE-HF, NCT04083339.
Fichier principal
Vignette du fichier
s12933-024-02135-z.pdf (1.07 Mo) Télécharger le fichier
12933_2024_2135_MOESM1_ESM.pdf (334.93 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04435381 , version 1 (02-02-2024)

Licence

Paternité

Identifiants

Citer

James L Januzzi, Stefano del Prato, Julio Rosenstock, Javed Butler, Justin Ezekowitz, et al.. Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial. Cardiovascular Diabetology, 2024, 23 (1), pp.49. ⟨10.1186/s12933-024-02135-z⟩. ⟨hal-04435381⟩
18 Consultations
8 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More