Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study - Université de Lorraine
Journal Articles European Heart Journal Year : 2024

Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study

Mathieu Echivard (1, 2) , Jean-Marc Sellal (1, 2, 3) , Chloé Ziliox (1, 2) , Eloi Marijon (4, 5) , Pierre Bordachar (6, 7, 8) , Sylvain Ploux (6, 7, 8) , Karim Benali (7, 6, 8) , Christelle Marquié (9, 10) , Clémence Docq (9, 10) , Didier Klug (9, 10) , Romain Eschalier (11, 12) , Baptiste Maille (13, 14) , Jean-Claude Deharo (13, 14) , Dominique Babuty (15, 16) , Thibaud Genet (15, 16) , Estelle Gandjbakhch (17, 18, 19) , Antoine da Costa (20, 21) , Olivier Piot (22) , Damien Minois (23, 24) , Jean-Baptiste Gourraud (23, 24) , Pierre Mondoly (25) , Philippe Maury (25, 26, 27) , Serge Boveda (28) , Jean-Luc Pasquié (29, 30) , Raphaël Martins (31, 32) , Christophe Leclercq (31, 32) , Charles Guenancia (33, 34) , Gabriel Laurent (33, 34) , Mathieu Becker (35) , Julien Bertrand (35) , Philippe Chevalier (36, 37) , Vladimir Manenti (38, 39) , Maciej Kubala (40, 41) , Pascal Defaye (42, 43) , Peggy Jacon (42, 43) , Antoine Desbiolles (42, 43) , Marc Badoz (44, 45) , Laurence Jesel (46, 47) , Nicolas Lellouche (48, 49) , Paul-Ursmar Milliez (50, 51) , Paul Ollitrault (50, 51) , Samir Fareh (52, 37) , Matthieu Bercker (53) , Jacques Mansourati (54, 55) , Benoît Guy-Moyat (56, 57) , Jean-Pierre Chabert (58, 59) , Nicolas Luconi (58) , Pierre-François Winum (60) , Frédéric Anselme (61, 62) , Fabrice Extramiana (63, 64) , Camille Delahaye (65) , François Jourda (66) , Olivier Bizeau (67) , Mathieu Nasarre (67) , Arnaud Olivier (68) , Stéphane Fromentin (69) , Thibault Villemin (70) , Olivier Levavasseur (71) , Néfissa Hammache (1, 2) , Isabelle Magnin-Poull (1, 2) , Hugues Blangy (1, 2) , Nicolas Sadoul (1, 2) , Kevin Duarte (72, 73, 74) , Nicolas Girerd (72, 73, 74) , Christian de Chillou (1, 3)
1 Service de Cardiologie [CHRU Nancy]
2 UL - Université de Lorraine
3 IADI - Imagerie Adaptative Diagnostique et Interventionnelle
4 HEGP - Hôpital Européen Georges Pompidou [APHP]
5 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
6 Hôpital Haut-Lévêque [CHU Bordeaux]
7 IHU-LIRYC
8 UB - Université de Bordeaux
9 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
10 Université de Lille
11 UCA - Université Clermont Auvergne
12 CHU Clermont-Ferrand
13 TIMONE - Hôpital de la Timone [CHU - APHM]
14 AMU - Aix Marseille Université
15 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
16 UT - Université de Tours
17 CHU Pitié-Salpêtrière [AP-HP]
18 SU - Sorbonne Université
19 IHU ICAN - Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière]
20 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
21 UJM - Université Jean Monnet - Saint-Étienne
22 CCN - Centre cardiologique du Nord
23 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
24 Nantes Univ - Nantes Université
25 Service Cardiologie [CHU Toulouse]
26 UT - Université de Toulouse
27 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
28 Clinique Pasteur [Toulouse]
29 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
30 UM - Université de Montpellier
31 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
32 UR - Université de Rennes
33 CHU Dijon
34 UB - Université de Bourgogne
35 CHR Metz-Thionville - Centre hospitalier régional Metz-Thionville
36 Hôpital Louis Pradel [CHU - HCL]
37 UCBL - Université Claude Bernard Lyon 1
38 Hôpital Privé Jacques Cartier [Massy]
39 Centre Hospitalier Privé Claude Galien - Ramsay Santé
40 CHU Amiens-Picardie
41 UPJV - Université de Picardie Jules Verne
42 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
43 UGA - Université Grenoble Alpes
44 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
45 UFC - Université de Franche-Comté
46 UNISTRA - Université de Strasbourg
47 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
48 CHU Henri Mondor [Créteil]
49 UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12
50 UNICAEN - Université de Caen Normandie
51 CHU Caen
52 Hôpital de la Croix-Rousse [CHU - HCL]
53 Centre Hospitalier Boulogne-sur-mer
54 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
55 UBO - Université de Brest
56 UNILIM - Université de Limoges
57 CHU Limoges
58 URCA - Université de Reims Champagne-Ardenne
59 CHU Reims - Hôpital universitaire Robert Debré [Reims]
60 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
61 UNIROUEN - Université de Rouen Normandie
62 CHU Rouen
63 CIC Hôpital Bichat
64 UPCité - Université Paris Cité
65 Centre Hospitalier de Roubaix
66 CHA - Centre hospitalier d'Auxerre
67 CHRO - Centre Hospitalier Régional d'Orléans
68 Clinique Pasteur
69 HNFC - Hôpital Nord Franche-Comté [Hôpital de Trévenans]
70 Polyclinique Reims-Bezannes
71 Hôpital Nord-Ouest [Villefranche sur Saône]
72 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
73 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
74 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
Pierre Mondoly
Serge Boveda
Gabriel Laurent
Mathieu Nasarre
Arnaud Olivier
  • Function : Author

Abstract

Background and Aims Prophylactic implantable cardioverter–defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e. within 3 months of hospital discharge) has not yet been specifically evaluated in post-myocardial infarction patients with impaired LVEF. Such was the aim of this retrospective study. Methods Data analysis was based on a nationwide registry of 1032 consecutive patients with LVEF ≤ 35% after acute myocardial infarction who were implanted with an ICD after being prescribed a wearable cardioverter–defibrillator (WCD) for a period of 3 months upon discharge from hospital after the index infarction. Results ICDs were implanted either because a sustained VA occurred while on WCD (VA+/WCD, n = 72) or because LVEF remained ≤35% at the end of the early post-infarction phase (VA−/WCD, n = 960). The median follow-up was 30.9 months. Sustained VAs occurred within 1 year after ICD implantation in 22.2% and 3.5% of VA+/WCD and VA−/WCD patients, respectively (P < .0001). The adjusted multivariable analysis showed that sustained VAs while on WCD independently predicted recurrence of sustained VAs at 1 year (adjusted hazard ratio [HR] 6.91; 95% confidence interval [CI] 3.73–12.81; P < .0001) and at the end of follow-up (adjusted HR 3.86; 95% CI 2.37–6.30; P < .0001) as well as 1-year mortality (adjusted HR 2.86; 95% CI 1.28–6.39; P = .012). Conclusions In patients with LVEF ≤ 35%, sustained VA during the early post-infarction phase is predictive of recurrent sustained VAs and 1-year mortality.
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Dates and versions

hal-04703968 , version 1 (20-09-2024)

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Mathieu Echivard, Jean-Marc Sellal, Chloé Ziliox, Eloi Marijon, Pierre Bordachar, et al.. Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study. European Heart Journal, 2024, Online ahead of print. ⟨10.1093/eurheartj/ehae575⟩. ⟨hal-04703968⟩
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