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ABCD : Etude de l'incidence précoce de l'asthme professionnel chez de jeunes travailleurs exerçant dans des professions à risque et investigations de ses facteurs de risque

Abstract : Context - Regarding the natural history of occupational asthma (OA), there is increasing evidence that the inflammatory process leading to clinical asthma appears early after inception of exposure. The ABCD study (French acronym for early asthma in bakery and hairdressing) aims to answer two objectives: 1) describe the temporal evolution of the OA incidence in the early years of exposure of bakers/pastry-makers (BP) and hairdressers - occupations known at risk of OA - and 2) identify personal, occupational and nutritional risk factors. Method - The ABCD study has two intertwined facets: (i) a retrospective longitudinal cohort of past apprentices of increasing seniority allowing to estimate the early incidence of OA, and (ii) a nested case-control study allowing to explore some risk factors of OA. Results - 866 subjects participated to the study. The ABCD study shows a high cumulative incidence of OA during the first 4 years of exposure among BP, and in a lesser extent, among hairdressers. While the OA risk depends on atopic status for BP, it is positively associated, for hairdressers, with exposure intensity and, to a lesser extent, to body mass index and with a variety of nutritioal factors. Conclusions - This study produced original data on early incidence of OA. These data may provide support for the development of preventive action, in particular for the detection of OA in the early years of exposure.
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https://hal.univ-lorraine.fr/tel-01746256
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Thomas Remen. ABCD : Etude de l'incidence précoce de l'asthme professionnel chez de jeunes travailleurs exerçant dans des professions à risque et investigations de ses facteurs de risque. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10117⟩. ⟨tel-01746256⟩

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