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Optimisation de la dosimétrie appliquée en thérapie photodynamique pour l'évaluation et la prédiction de l'efficacité du traitement de tumeurs

Abstract : Photodynamic therapy (PDT) is a therapeutic strategy for the treatment of small localized tumors accessible to the visible light irradiation. It is based on the combined action of photosensitizer (PS), light and molecular oxygen. Tumoricidal effect of PDT is triggered by direct damage of malignant cells and indirect vascular damage followed by an activation of the immune system. The present study investigates the relationship between photoinduced apoptosis in each compartment of interest (vascular versus neoplastic) and mTHPC-PDT treatment efficiency in function of the intratumoral distribution of mTHPC. The latter was defined by the drug-light intervals. In the first part, we demonstrated the importance of the intratumoral distribution of mTHPC to optimize photodynamic parameters. The fractionation of the PS administration permitted to obtain a tumor cure rate of 100% correlated to a massive apoptosis of pathological tissues. Moreover, this treatment strategy induced only limited skin damages and few inflammation which could be an advantage in clinical context. In the second part, we evidenced the mTHPC redistribution from liposomal formulations (Foslip®, Fospeg®) in vivo in the chick chorioallantoic membrane model (CAM) and its influence on photoinduced vascular damage
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https://hal.univ-lorraine.fr/tel-01746258
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Julie Garrier. Optimisation de la dosimétrie appliquée en thérapie photodynamique pour l'évaluation et la prédiction de l'efficacité du traitement de tumeurs. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10112⟩. ⟨tel-01746258⟩

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