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Nouvelle voie d'accès à des dérivés de l'acide L-iduronique

Abstract : The aim of this work is the conception of a new synthetic approach to L-iduronic acid derivatives, a saccharidic sub-unit part of glycosaminoglycans like heparin. The starting materials used for this synthesis are glucose derivatives, a cheap and abundant sugar. The strategy of the synthesis was to obtain an L-ido derivative from a D-gluco one, by performing an inversion of configuration at position 5. The first part of this work deals with the different reactions leading to the inversion of configuration. The second part concerns the way to obtain L-iduronic acid derivatives by the above studied reactions along with synthesis optimisation
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https://hal.univ-lorraine.fr/tel-01746327
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Stéphane Salamone. Nouvelle voie d'accès à des dérivés de l'acide L-iduronique. Autre. Université Henri Poincaré - Nancy 1, 2010. Français. ⟨NNT : 2010NAN10056⟩. ⟨tel-01746327⟩

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