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Calixarènes hydrosolubles à propriétés antivirales et antibactériennes

Abstract : The present work is integrated in a research dedicated to the role that calixarene macrocycles can play in the medicinal field particulary infectiology, throught their spatial organizing properties for various ionic groups. We have notably targetted the very sensitive virology and bacteriology domains, for which the research and the discovery of new therapeutical approaches and of new lead compounds become crucial. Once designed, according to the inhibition of virus/cell adhesion process or the denaturation of bacterial membrane, we estimate the impact of our compounds, all hydrosoluble, on the main bacterial strains involved in infections, notably the nosocomial ones, and enveloped viruses such as Herpes and virus associated to AIDS, HIV. These water soluble compounds bearing or not heterocyclic groups being always rare, led us to establish a state-of-the-art on the hydrosolubilisation of calixarenes, introduction of nitrogenous heterocycles, as well as their therapeutical implications. In a second part, we present and discuss the synthetic strategies and results obtained with three new anionic or cationic calixarene families. The third part presents the antiviral and antibacterial properties of the above-mentioned compounds. We present the antiviral activities on HSV obtained with previously developed compounds, then their anti-HIV activities and those of compounds prepared during the present work. Finally, we present and discuss the results concerning their antibacterial activities obtained on various Gram+ and Gram- bacterial strains.
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Submitted on : Thursday, March 29, 2018 - 10:40:18 AM
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  • HAL Id : tel-01746559, version 1



Maxime Mourer. Calixarènes hydrosolubles à propriétés antivirales et antibactériennes. Autre. Université Henri Poincaré - Nancy 1, 2006. Français. ⟨NNT : 2006NAN10168⟩. ⟨tel-01746559⟩



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