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Theses

La plaque cartilagineuse vertébrale. Sa place dans la pathologie discale

Abstract : The cartilaginous end-plate (CEP) is the anatomic limit between the vertebra and the intervertebral disc (IVD). Since the latter is avascular in adults, the CEP is supposed to play a key role in the metabolism of the IVD. Consequently, it has been postulated that the decrease in permeability of the CEP is the main cause of disc degeneration. However, the permeability depends at least partially on the morphological state of the CEP, and few studies have been carried out on this subject. In addition, little is known about the age-related changes of the CEP compared to those of the IVD. After a review of the literature dealing with the CEP and the pathogenesis of disc degeneration, the results of research works on the CEP are presented. The objectives of the main study were to examine the CEP of fifty intervertebral disks of human lumbar spines, to classify the age-related changes in both CEP and IVD, and to compare them. No significant difference was found with regard to these features in the different age groups and no significant correlation was found between the morphological grade of the CEP and that of the IVD, suggesting that the importance of the CEP in disc degeneration is open to debate. The development, the vascular supply and the ultrastucture of the IVD were also studied. Finally, the value of comparing the human joint of vertebral bodies to a diarthrodial joint is discussed in the light of these different points of view.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2000_0297_GRIGNON.pdf
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https://hal.univ-lorraine.fr/tel-01746888
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Submitted on : Thursday, March 29, 2018 - 10:46:59 AM
Last modification on : Thursday, January 7, 2021 - 3:05:30 PM

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Bruno Grignon. La plaque cartilagineuse vertébrale. Sa place dans la pathologie discale. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2000. Français. ⟨NNT : 2000NAN10297⟩. ⟨tel-01746888⟩

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