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Allogreffes artérielles et cryoconservation : approche biomécanique et aspects cliniques

Abstract : Transplantation of arteries is today the forefront of the surgical and scientific news in vascular pathology. The use of human arterial grafts, inevitably preserved during at least four months in tissue banks, in accordance with the French legislation on microbiological security, implies the necessity of a method of long conservation. This method should not alter structural and mechanical properties of the grafts. The purpose of this study is to evaluate the impact of cryopreservation parameters on the structure and mechanical graft properties. The applications of this study are the optimization of cryconservation techniques of arterial grafts to provide for patients reliable and quality arterial grafts; furthermore, an in vivo study of the thawed grafts allows to envisage an optimized transplant; a perspective of transplantation of cellular grafts is envisaged.
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Submitted on : Thursday, March 29, 2018 - 10:47:00 AM
Last modification on : Thursday, December 17, 2020 - 2:11:02 PM

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Bertrand Lehalle. Allogreffes artérielles et cryoconservation : approche biomécanique et aspects cliniques. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2000. Français. ⟨NNT : 2000NAN10298⟩. ⟨tel-01746889⟩



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