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Action antagoniste de la glucosamine sur les effets délétères de l'interleukine-1 ou des compressions mécaniques sur la synthèse des protéoglycanes dans des cultures chondrocytaires

Abstract : Early stages of articular disease are characterized by a breakdown of cartilage homeostasis notably due to a biosynthesis inhibition of matricial components. Our works concerns the IL-1 and mechanical compression deleterious effects in an articular cartilage damage observed in an origjnal model of chondrocyte culture .We first have determined the krey role of GIcAT-I (an enzyme implicated in GAG elongation chain) on the decrease of PG synthesis. Moreover, we have shown that glucosamine reserves the IL-1 mechanical compression-mediated effects on anabolic, catabolic enzymes and on differents pro-inflammatory parameters. The glucosamine beneficial effects can be in part explained by an action at the receptorial level and on activation of NF-kB. This study improves knowledge of beneficial glucosamine effects on articular osteoarthritic cartilage by the identification of two targets on IL-1 signaling pathways.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2000_0314_GOUZE.pdf
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https://hal.univ-lorraine.fr/tel-01746911
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Submitted on : Thursday, March 29, 2018 - 10:47:27 AM
Last modification on : Friday, February 26, 2021 - 3:00:04 PM

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  • HAL Id : tel-01746911, version 1

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Jean-Noël Gouze. Action antagoniste de la glucosamine sur les effets délétères de l'interleukine-1 ou des compressions mécaniques sur la synthèse des protéoglycanes dans des cultures chondrocytaires. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2000. Français. ⟨NNT : 2000NAN10314⟩. ⟨tel-01746911⟩

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