Skip to Main content Skip to Navigation
Theses

Déterminants nutritionnels et génétiques de l'homocystéine et méthylation de l'ADN : modèles expérimentaux et implications en pathologie

Abstract : DNA methylation is an essential mechanism for epigenetic control of genes expression and for maintenance of genome integrity. Determinant of methionine synthase and DNA hypomethylation are not clear. Low blood folate, is the main determinant of hyperhomocysteinemia, while low vitamin B12 affects methionone synthase activity and DNA hypomethylation. Vitamin B12 affects methionine synthase expression by a non -transcriptional mechanism different from a prospective effect on MTR proteolysis. Nutritional determinants of DNA hypomethylation also have a variable effect on liver carcinogenesis. Choline/methionine and/or folate deficient diets are responsible for an incidence of 20% to 50% of hepatocarcinoma decrease and is estimated to < 5%. The use of histone decetylase inhibitors (Trichostatin A) induces an increase of mRNA of genes that are involved in iodine captation by thyroïd cancer cells. This could be used in clinical trials. Genetic deteminants of hyperhomocysteinemia and hypomethylation are involved in Alzheimer's disease severity and in the pathophysiologie of Down syndrome and neural tube defects.
Document type :
Theses
Complete list of metadata

https://hal.univ-lorraine.fr/tel-01746923
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 10:47:52 AM
Last modification on : Wednesday, May 20, 2020 - 10:09:32 AM
Long-term archiving on: : Thursday, September 13, 2018 - 1:21:56 PM

File

SCD_T_2003_0235_BRUNAUD.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01746923, version 1

Collections

Citation

Laurent Brunaud. Déterminants nutritionnels et génétiques de l'homocystéine et méthylation de l'ADN : modèles expérimentaux et implications en pathologie. Biologie cellulaire. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN11305⟩. ⟨tel-01746923⟩

Share

Metrics

Record views

188

Files downloads

460