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Theses

Triggering Receptor Expressed on Myeloid cells-l : implications diagnostiques et thérapeutiques au cours du sepsis

Abstract : Sepsis induces a strong up-regulation of membrane-bound TREM-1 expression, together with a release of its soluble form, both in humans and mice. This phenomenon is confined to bacterial ligands but not a result of TNF-[exposant alpha] production, and involves a P13K-dependent mechanism sTREM-1 decreases pro-inflammatory cytokines production in mice. The assessment of sTREM-1 concentration in biological fluids, and especially plasma and BAL fluids, is useful in distinguishing infected patients from patients suffering from inflammatory disorder of non-infectious origin. A progressive declining of sTREM-1 levels during the recovery phase of sepsis may comfort clinicians with the accuracy of therapy. TREM-1 appears to be a crucial player during the early immune response. Upon recognition of its still unknown ligand, the engagement of TREM-1 leads to an amplification of the inflammatory response. The modulation of TREM-1 signalling reduces, although without complete inhibition, cytokine production and protects animals from hyper-responsiveness and death. The use of a modular peptide might be a suitable therapeutic tool for the treatment of sepsis, particularly because it seems to be active even after the onset of infectious agression.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2004_0245_GIBOT.pdf
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Submitted on : Thursday, March 29, 2018 - 10:48:10 AM
Last modification on : Wednesday, September 2, 2020 - 3:32:05 PM

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Sébastien Gibot. Triggering Receptor Expressed on Myeloid cells-l : implications diagnostiques et thérapeutiques au cours du sepsis. Sciences agricoles. Université Henri Poincaré - Nancy 1, 2004. Français. ⟨NNT : 2000NAN10245⟩. ⟨tel-01746941⟩

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