Etude expérimentale de la toxicité articulaire des fluoroquinolones chez le rongeur : arguments physiopathologiques en faveur d'un stress oxydant

Abstract : Even if some infrequent adverse reactions occur during their use, fluoroquinolones have been reported to promote chondrotoxicity and tendinopathy. In this study, we investigated the pathophysiological mechanism involved in these both effects. A transitory hypomobility was observed by biotelemetric study. Proteoglycan synthesis decreased in both tendon and articular cartilage 24 hours after a single administration of pefloxacin. This inhibition was followed by a repair-like phase in Achilles tendon only. Pefloxacin treatment during several days induced an oxidative damage to articular and tendinous collagens, and we observed a significant IL1 mRNA expression. These modifications were identical to those observed in an experimental ischaemia-reperfusion of the tendon. Moreover, pefloxacin-induced oxidative damage was prevented by co-administration of NAC in Achilles tendon. Both a pefloxacin treatment during several days and the tendinous ischaemia-reperfusion induced type III collagen RNAm expression in Achilles tendon, thus underlining a wound-healing phenomenon. This study suggests a common pathophysiological pathway, involving an oxidative stress, during both fluoroquinolone-induced chondrotoxicity and tendinopathy.
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http://docnum.univ-lorraine.fr/prive/SCD_T_1999_0328_SIMONIN.pdf
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Submitted on : Thursday, March 29, 2018 - 10:51:07 AM
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Marie-Agnès Simonin. Etude expérimentale de la toxicité articulaire des fluoroquinolones chez le rongeur : arguments physiopathologiques en faveur d'un stress oxydant. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 1999. Français. ⟨NNT : 1999NAN10328⟩. ⟨tel-01747106⟩

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