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Anion oxalyle équivalent : alkylation fonctionnalisante stéréospécifique en série stéroïde

Abstract : [alpha]-chloroglycidic ester derived from 5[alpha]-cholestan-3-one was thermally transposed to yield exclusively a chlorinated cetoester at equatorial halogen. This could be transformed in a stereospecific fashion into hydroxycetoester at axial hydroxyl group via the corresponding epoxyether. The réactions of the amines on [alpha]-chloroglycidic ester and the [alpha]-chlorocetoester enhance an stereospecific access to the diastereoisomeric aminocetoesters carrying the aminated group in equatorial and axial configuration respectively.
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https://hal.univ-lorraine.fr/tel-01747179
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Submitted on : Thursday, March 29, 2018 - 10:54:15 AM
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Jacques Amos. Anion oxalyle équivalent : alkylation fonctionnalisante stéréospécifique en série stéroïde. Autre. Université Henri Poincaré - Nancy 1, 1990. Français. ⟨NNT : 1990NAN10493⟩. ⟨tel-01747179⟩

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