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Effet protecteur du calcium alimentaire lors de la carcinogenèse colique chimio-induite chez le rat Wistar

Abstract : The aim of the study was fa evaluate in Wistar rats the promoting effect of poiyunsaturated (n-6)or saturated (végétaline) fats (24%) in colon carcinogenesis and the influence of supplemental calcium(1.5%) in this process. NMU was intrarectally instillated to induce colon carcinogenesis. Three different calcium salts (carbonate, lactate, and gluconate) were tested. Colon cancer incidence was higher in rats fed saturated fats than in those consuming unsaturated ones.The calcium supplementalion exhibits a protective effect depending on the chemical form used.Calcium lactate provide better protection than carbonate or gluconate.From the parameters those were used to follow carcinogenesis, resulls indicate that calcium salt acts through several ways, luminal and systemic. It chelates fatty acids and bile acids in the lumen and modulates the microbial transformations of cholesterol and bile acids, thus reflecting a modification of the intestinal microflora. The calcium balance suggests that the proteclive effect of calcium lactate is also efficient in reducing the cellular proliferation. Laminin P1 is proposed as a possible tumoral marker. Its serum levels are associated with colon tumorigenesis.
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Slimane Belbraouet. Effet protecteur du calcium alimentaire lors de la carcinogenèse colique chimio-induite chez le rat Wistar. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 1994. Français. ⟨NNT : 1994NAN10021⟩. ⟨tel-01747486⟩



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