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Aspects fonctionnels et structuraux des systèmes thiorédoxine et glutarédoxine de peuplier et de leurs enzymes cibles, les peroxyrédoxines et les méthionine sulfoxyde réductases de type A

Abstract : Cellular metabolism leads to the production of reactive oxygen species (ROS) which are extremely damaging to macromolecules including proteins and lipids. By maintaining the redox equilibrium, the thioredoxin and glutaredoxin systems help fight the damages generated by the ROS. Two thioredoxins and one glutaredoxin, all bicysteinic, have been chracterized and their catalytic mechanism detailed. This work has also focused on two thioredoxin/ glutaredoxin target enzymes, peroxiredoxins which are peroxydases devoid of prosthetic group and type A methionine sulfoxide reductases, which reduce S methionine sulfoxide into methionine.The structural and functional characterization of several peroxiredoxin and type A methionine sulfoxide reductases has led to the identification of the active site amino acids as well as those necessary for the protein/protein interactions. The most original result is that glutaredoxin can serve as an alternative and preferential electron donor for a certain class of peroxiredoxins.
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https://hal.univ-lorraine.fr/tel-01748118
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Submitted on : Thursday, March 29, 2018 - 11:25:33 AM
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  • HAL Id : tel-01748118, version 1
  • PRODINRA : 277459

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Nicolas Rouhier. Aspects fonctionnels et structuraux des systèmes thiorédoxine et glutarédoxine de peuplier et de leurs enzymes cibles, les peroxyrédoxines et les méthionine sulfoxyde réductases de type A. Biologie végétale. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN10104⟩. ⟨tel-01748118⟩

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