Etude IRM du vieillissement articulaire à 1.5 et 7 Teslas : Approches volumiques et cartographiques

Abstract : Osteoarthritis (OA) is a common disease observed in elderly population and characterized by a progressive destruction of cartilaginous tissue. The clinical diagnosis of this disease is realized by conventional radiography. This method allows visualizing bone modifications related to OA disease (cysts, subchondral bone thickening, and osteophytes) but is unable to assess directly cartilage structure. Due to its high spatial resolution and high contrast between tissues, Magnetic Resonance Imaging (MRI) is able to visualize the cartilage structure and to differentiate it from adjacent structures (bone, synovial tissue, menisci, and synovial fluid). We have employed MRI potentialities at high magnetic field (7 Teslas) to follow, in vivo, cartilage modifications in the rat femoro-tibial articulation. This methodology was used to evaluate normal cartilage ageing-process and to assess an experimental OA model (anterior cruciate ligament transaction). These works showed an age-related cartilage volumetric and thickness decrease, as well as femoral cartilage damages and tibial cartilage oedema in OA knees. In a second part of our work, we applied T2 mapping and volumetric techniques (at 1.5 T) to determine variations which occur in the elderly human patellar cartilage. Results demonstrated the capacity of T2 mapping to early detect matricial modifications before any cartilage volumetric impact can be found. At least, our last study, always at 1.5 T, focused on the synovial membrane volume and inflammatory activity by taking into account a human population suffering from knee OA.
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Jean-Christophe Goebel. Etude IRM du vieillissement articulaire à 1.5 et 7 Teslas : Approches volumiques et cartographiques. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2009. Français. ⟨NNT : 2009NAN10108⟩. ⟨tel-01748500⟩

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