Nouvelles approches méthodologiques pour l'évaluation du vieillissement des gros troncs artériels par l'étude de la distensibilité artérielle et de l'analyse de la courbe de la pression artérielle chez l'homme

Abstract : The object of this thesis is conception, validation and development of PulsePen® tonometer and study of new methods to evaluate the aging of aorta and its principal branches. Three devices currently used in clinical practice to determine pulse wave velocity, using three different methods, were compared. This study confirmed the reliability of PulsePen® and Complior® devices to investigate the viscoelastic properties of the large arteries. Reference values of pulse wave velocity in children and teenagers were defined in a multicentric study. This study provided the percentiles of reference values depending on age and height. The multicentric study PARTAGE identified the reference values of pulse wave velocity about a population of elderly aged >80 years. This study demonstrated that pulse wave velocity and blood pressure amplification are complementary methods in studying cardiovascular risk and that pulse wave velocity is more linked to major cardiovascular risk factors, whereas blood pressure amplification is strongly linked to the presence of heart disease and for which low values can be considered as the expression of cardiac damage in elderly. Finally the relationship between arterial stiffness and atherosclerosis was studied, besides the influence of factors determining metabolic syndrome on intima-media thickness and pulse wave velocity. The independent and significant role of non alcoholic fatty liver disease on arterial stiffness was shown.
Document type :
Theses
Complete list of metadatas

Cited literature [104 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01748551
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 11:38:02 AM
Last modification on : Monday, April 16, 2018 - 10:40:19 AM
Long-term archiving on : Friday, September 14, 2018 - 10:22:14 AM

File

SCD_T_2010_0048_SALVI.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01748551, version 1

Collections

Citation

Paolo Salvi. Nouvelles approches méthodologiques pour l'évaluation du vieillissement des gros troncs artériels par l'étude de la distensibilité artérielle et de l'analyse de la courbe de la pression artérielle chez l'homme. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2010. Français. ⟨NNT : 2010NAN10048⟩. ⟨tel-01748551⟩

Share

Metrics

Record views

21

Files downloads

23