Skip to Main content Skip to Navigation
Theses

Synthèse et étude conformationnelle de nouveaux oligomères mixtes : les [[alpha]/[alpha]-N-amino]mères

Abstract : This work describes the synthesis and the conformational study of new mixed oligomers. In the first chapter, using previous work on the synthesis of N-aminodipeptids, we were obtained mixed oligomers alternating amid and N-aminoamid bond named [[alpha]/[alpha]-N-amino]mers. The oligomerization of N-aminopeptids in liquid phase was achieved through an acid fluorid coupling from a building block with the protections Boc (N-terminus), Bn (C-terminus) and phtaloyl (N-side). The second chapter presents the results obtained by different conformational spectroscopic methods (NMR, IR and DC) and molecular modeling on the various oligomers synthesized in Chapter 1. This work has allowed to highlight a original repetitive folding by a C8 hydrogen bond involving the carbonyl group of phthalimid and a amid proton
Document type :
Theses
Complete list of metadatas

Cited literature [14 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01748726
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 11:47:19 AM
Last modification on : Friday, February 26, 2021 - 2:30:04 PM
Long-term archiving on: : Friday, September 14, 2018 - 9:53:28 AM

File

2009_DAUTREY_S.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01748726, version 1

Citation

Sébastien Dautrey. Synthèse et étude conformationnelle de nouveaux oligomères mixtes : les [[alpha]/[alpha]-N-amino]mères. Autre. Institut National Polytechnique de Lorraine, 2009. Français. ⟨NNT : 2009INPL053N⟩. ⟨tel-01748726⟩

Share

Metrics

Record views

29

Files downloads

59