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Synthèse et étude conformationnelle de nouveaux oligomères mixtes : les [[alpha]/[alpha]-N-amino]mères

Abstract : This work describes the synthesis and the conformational study of new mixed oligomers. In the first chapter, using previous work on the synthesis of N-aminodipeptids, we were obtained mixed oligomers alternating amid and N-aminoamid bond named [[alpha]/[alpha]-N-amino]mers. The oligomerization of N-aminopeptids in liquid phase was achieved through an acid fluorid coupling from a building block with the protections Boc (N-terminus), Bn (C-terminus) and phtaloyl (N-side). The second chapter presents the results obtained by different conformational spectroscopic methods (NMR, IR and DC) and molecular modeling on the various oligomers synthesized in Chapter 1. This work has allowed to highlight a original repetitive folding by a C8 hydrogen bond involving the carbonyl group of phthalimid and a amid proton
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Sébastien Dautrey. Synthèse et étude conformationnelle de nouveaux oligomères mixtes : les [[alpha]/[alpha]-N-amino]mères. Autre. Institut National Polytechnique de Lorraine, 2009. Français. ⟨NNT : 2009INPL053N⟩. ⟨tel-01748726⟩



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