Contribution mécanique à la réduction des marges en radiothérapie de la prostate : modélisation et simulation numérique du mouvement et de la déformation des organes pelviens

Abstract : 'The prostate plays an important biological role in the human body, such as secretion of some prostatic liquid essential in the semen composition. Prostate cancer is the first cause of mortality for men at an advanced age. The prostate motion due to the interactions with the surrounding anatomic entities is difficult to predict, hence important margins are usually adopted during X-ray irradiation, in order not to damage the surrounding healthy organs (bladder and rectum). The principal objective of this work is to set up a FE model of the motion and deformation of the human pelvic organs in order to reduce the margins. A first model is constructed from CT-scans of the human pelvic organs, allowing the generation of the organ geometrics. Hyperelastic modeling of the bladder and rectum behaviors were considered whereas a Hookean model was retained for the prostate. The model parameters are fixed by adopting literature data, experimental data (from CHU-Nancy) and experimental measurements achieved on pig. Boundary conditions are defined according either surrounding anatomy kinematic constraints or internal pressures that correspond to the bladder and rectum repletion's. Simulated displacements show order of magnitudes of the prostate motion very close to measurements carried out by Keros et al. (2006) on a deceased person, with a relative error ranging from 8% to 11%. Those differences are essentially due to the variability in the physical parameters, pointing out the need for a statistical approach in order to take into account the material, geometrical and loading variability related to a panel of patients
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Mohamed Bader Boubaker. Contribution mécanique à la réduction des marges en radiothérapie de la prostate : modélisation et simulation numérique du mouvement et de la déformation des organes pelviens. Autre. Institut National Polytechnique de Lorraine, 2009. Français. ⟨NNT : 2009INPL089N⟩. ⟨tel-01748742⟩

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