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Étude des interactions polluants aromatiques polycycliques (HAP)-récepteurs adrénergiques-phospholipides membranaires dans le tissu adipeux

Abstract : Obesity is a disease defined by an accumulation of fat in adipose tissue with adverse consequences for health. The causes of obesity are many.In recent work, there was demonstrated the role of environmental pollution in weight gain.In this work, the assumptions that the adrenergic receptors on the surface of fat cells would home to the accumulation of polycyclic aromatic pollutants have been verified by measurement of several agonists and antagonists specific and non-specific in the presence or absence of benzo[a]pyrene receptors on human cells and Chinese hamster (CHO). The amounts of cAMP obtained showed that PAHs are not deposited on b-receptors, b1, b2, b3 adrenergic receptors.This accumulation occurs at the cytoplasmic membrane phospholipids of the cells. What cau-ses stiffness of the membranes. This observation tends to reinforce the hypothesis that benzo [a]pyrene induce an inhibition of lipolysis by the accumulation in the phospholipid bilayer and conformational changes of the bilayer phospholipids in the vicinity of receptors seven transmembrane domains which are b-adrenergic receptors
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Akouavi Balbine Fagla-Amoussou. Étude des interactions polluants aromatiques polycycliques (HAP)-récepteurs adrénergiques-phospholipides membranaires dans le tissu adipeux. Sciences agricoles. Institut National Polytechnique de Lorraine, 2010. Français. ⟨NNT : 2010INPL080N⟩. ⟨tel-01748848⟩

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