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Conception, élaboration et caractérisation photophysiques et biochimiques de molécules photoactivables pour la thérapie photodynamique

Abstract : Angiogenesis is a key step in the tumoral progression process. It is characterized by an over-expression of a number of matrix metalloproteinases (MMP). Among these MMPs, gelatinases (MMP-2 and MMP-9) are known to play a critical role in tumor angiogenesis and the growth of many cancers. Photodynamic Molecular Beacons (PMB) can be designed for cancer treatment by associating a chlorin-like photosensitizer and a black hole quencher linked by a gelatinase substrate peptide with the aim of silencing photosensitizer toxicity in non-targeted cells and restore its toxicity only in surrounding gelatinases. We investigated the PS/quencher pair allowing the best singlet oxygen production inhibition, and then we synthesized a novel family of PMB triggering gélatinases MMP-2 and MMP-9. Different lengths of peptide and spacers were used in order to determinate the influence of the distance between PS and quencher on the PMB photophysical properties and enzymatic activation.
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https://hal.univ-lorraine.fr/tel-01749388
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Submitted on : Thursday, March 29, 2018 - 12:15:00 PM
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  • HAL Id : tel-01749388, version 1

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Marc Verhille. Conception, élaboration et caractérisation photophysiques et biochimiques de molécules photoactivables pour la thérapie photodynamique. Médecine humaine et pathologie. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0194⟩. ⟨tel-01749388⟩

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