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Dosimétrie in vivo intracavitaire basée sur la luminescence stimulée optiquement de l'Al2O3:C dédiée à la curiethérapie

Estelle Spasic 1, 2
2 LCFO - Laboratoire Capteurs Fibres Optiques
DM2I - Département Métrologie Instrumentation & Information : DRT/LIST/DM2I
Abstract : The brachytherapy is an old technique using sealed radioactive sources of low or average energy. This technique is still therapeutically and economically relevant today and always evolving (e.g. High Dose Rate (HDR) brachytherapy). This treatment enables to deliver a high dose of irradiation in a limited tumoral volume and enables to minimize the risk of radiation-induced cancer as preserving the Organs at Risks (OAR). However, this technique generates high dose gradients, which makes in vivo dosimetry difficult to implement. Hence, the deviations observed between doses delivered and prescribed are often up to the maximal deviation tolerated by the nuclear safety regulations (± 5%) in conformational radiotherapy. Those regulations have been made mandatory in France since 2011. This thesis has been done within the framework of the ANR-TECSAN INTRADOSE project and is based on the past technological benefits demonstrated during the MAESTRO European project and the ANR-TECSAN CODOFER project, in particular a RL/OSL multichannel instrumentation (Radioluminescence - Optically Stimulated Luminescence) made and validated in preclinical evaluation during the MAESTRO project. The purpose of the INTRADOSE project is to demonstrate the feasibility of the intracavitary In Vivo Dosimetry (IVD) by dosimetric catheter using optical fibers and alumina crystals Al2O3:C with the aim of improving the safety of patients treated by HDR brachytherapy. This new probe enables to measure a dose distribution (several points) close to the OAR, it offers a little diameter (
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Estelle Spasic. Dosimétrie in vivo intracavitaire basée sur la luminescence stimulée optiquement de l'Al2O3:C dédiée à la curiethérapie. Autre [cond-mat.other]. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0270⟩. ⟨tel-01749394⟩



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