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Toxicité neurocomportementale à court et à long-terme du BDE-99 chez le rat adulte ou en développement : étude des effets de l'administration quotidienne par voie orale de doses représentatives de l'exposition humaine pendant 90 jours

Abstract : PBDEs belong to flame retardants, substances heavily used in recent decades. These molecules are now found ubiquitously in the environment outside and inside. Humans are exposed to these pollutants through diet and ingestion/inhalation of household dust or contaminated industrial dust. Their lipophilic properties and their persistence are the cause of their bioaccumulation in abiotic and biological matrices (milk, serum ...). The research works of this thesis was aimed to assess the impact of exposure to a toxic environmental pollutant and very prevalent, BDE-99, administered in conditions reflecting the human exposure. Thus, the effects of long-term exposure to realistic doses of BDE-99 (0.15, 1.5 and 15 µg/kg/day) were evaluated in terms neurobehavioral and physiological in male Sprague-Dawley rats. No alteration of the activity, anxiety and cognitive function has been highlighted that the animals were treated in adulthood, from weaning or from the 8th day of postnatal life. The only significant behavioral variations observed were transient locomotor coordination disorders and a delay of one day of eye opening in animals treated with BDE-99 from the age of 8 days. On a physiological level, no significant variation in body weight change, food and water consumption and weight of several organs (liver, brain, kidneys, spleen and thymus) was observed whatever the dose of BDE-99 administered and the exposure period considered. These results show that this pollutant administered to rats at realistic doses, reflecting those to which humans are actually exposed, is not able to induce neurobehavioral toxicity that the animal are contaminated in adulthood or at different phases of postnatal development. The fact to have used corresponding the level of environmental exposure is undoubtedly the basis of discrepancies observed between the results of this work and those of the published studies elsewhere, underscoring the necessity to realize exposure models the most possible relevant in order to able to conclude at best about risk associated with this family of contaminants to human health.
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Stéphanie Daubié-Albanese. Toxicité neurocomportementale à court et à long-terme du BDE-99 chez le rat adulte ou en développement : étude des effets de l'administration quotidienne par voie orale de doses représentatives de l'exposition humaine pendant 90 jours. Sciences agricoles. Institut National Polytechnique de Lorraine, 2011. Français. ⟨NNT : 2011INPL041N⟩. ⟨tel-01749483⟩

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