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Synthèse contrôlée de copolymères dextrane-g-polylactide : de leur utilisation comme surfactifs biodégradables à la mise en oeuvre de systèmes de vectorisation particulaires

Abstract : Synthesis of novel grafted amphiphilic copolymers polylactide-grafted dextran was achieved. Macromolecular control of such biodegradable and potentially biocompatible copolymers requires a three-step synthesis based on the "grafting from" concept : partial protection of the dextran hydroxyl groups by silylation ; followed by ring opening polymerization of D, L-lactide initiated from remaining hydroxyls of this partially silylated dextran backbone. The third step involves the silylethers deprotection under very mild conditions. Throughout the synthesis, detailed studies of each step have led to stability of dextran backbone and control of copolymer architecture in terms of graft number and graft length. Tension and fluorescence experiments have given information about the organisation properties of these copolymers. The potential of such copolymers for formulation of nanospheres has been also studied.
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https://hal.univ-lorraine.fr/tel-01749775
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Cécile Nouvel. Synthèse contrôlée de copolymères dextrane-g-polylactide : de leur utilisation comme surfactifs biodégradables à la mise en oeuvre de systèmes de vectorisation particulaires. Alimentation et Nutrition. Institut National Polytechnique de Lorraine, 2002. Français. ⟨NNT : 2002INPL104N⟩. ⟨tel-01749775⟩

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