Skip to Main content Skip to Navigation
New interface

Le choc anaphylactique : de la physiopathologie à la thérapeutique

Abstract : The aim of our work was to study new aspects of the pathophysiology and treatment of anaphylactic shock in the Brown Norway rat. The first part of this thesis focuses on the systemic and regional pathophysiology of anaphylactic shock which is accompanied by a rapid decrease in cardiac output, a sudden alteration of autoregulation of cerebral blood flow and a respiratory dysfunction involving swelling of the airways and bronchospasm. The second part of our work focuses on the therapeutic management of anaphylactic shock. Epinephrine was found to be superior to vasopressin, to inhibit bronchospasm and decrease microvascular permeability, allowing a better preservation of the cerebral oxygenation, in particular in the region of the hippocampus. Furthermore, it provided also an alleviation of bronchospasm and of bronchial hyperperméabilté in the early phase of anaphylactic shock. We also compared the effects of three types of fluid therapy administered in combination with adrenaline during anaphylactic shock, demonstrating the superiority of the administration of a macromolecular solution such as HES compared to hypertonic saline fluids. Finally we were able to highlight the usefulness of the administration of methylene blue (3mg/kg) demonstrating the existence of a synergistic effect with adrenaline during anaphylactic shock
Document type :
Complete list of metadata
Contributor : Thèses UL Connect in order to contact the contributor
Submitted on : Thursday, March 29, 2018 - 12:28:07 PM
Last modification on : Monday, October 19, 2020 - 11:10:25 AM
Long-term archiving on: : Friday, September 14, 2018 - 9:26:38 PM


Files produced by the author(s)


  • HAL Id : tel-01749801, version 1



Feng Zheng. Le choc anaphylactique : de la physiopathologie à la thérapeutique. Médecine humaine et pathologie. Université de Lorraine, 2013. Français. ⟨NNT : 2013LORR0063⟩. ⟨tel-01749801⟩



Record views


Files downloads