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Insuffisance cardiaque : épidémiologie, caractéristiques des patients et de leur prise en charge, et facteurs pronostiques de décès

Abstract : Context: Heart failure (HF) is a heterogeneous syndrome with various aetiologies. HF incidence increases with age, and the prognosis remains poor. Prognostic factors have been widely described in the literature, especially in HF with reduced ejection fraction with short-term or mid-term follow-up. Medications, surgical interventions, and complex interventions are part of the current guidelines. Objectives: To assess the prognostic value of fibrosis markers in hypertensive patients; to describe the survival and to detect prognostic factors, first at 15 years in HF patients with reduced ejection fraction (HFREF), and second at one year in HF patients with preserved ejection fraction (HFPEF); and to assess the prognostic impact of 2 complex interventions on HF hospitalisations. Methods: Cardiac extracellular matrix serum markers (CEMSM) were assessed at baseline in a first cohort of hypertensive patients followed-up for 6 years. Two other cohort studies were used to detect prognostic factors associated with very-long term mortality in HFREF (EPICAL), and with 1-year mortality in HFPEF (Odin). And the national diagnostic related group database was used to assess the prognostic impact of a HF unit (UTIC) and a disease management programme (ICALOR). Results: The first cohort study highlighted the prognostic value of CEMSM in hypertensive patients. In EPICAL study, older age, diabetes mellitus, chronic renal failure, time from HF onset, history of hospitalisations for worsening HF, tachycardia, a low left ventricular ejection fraction, and hyponatraemia were associated with a higher mortality in HFREF patients. In Odin study, we highlighted the negative prognostic impact of social factors, such as living alone or daily activity limitation, in HFPEF patients. Both UTIC and ICALOR were associated with a decrease in HF hospitalisations compatible with a population impact. Conclusion: These studies offer new insights for primary and secondary prevention strategies that could eventually lead to decrease HF incidence, HF morbidity, and HF mortality
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Submitted on : Thursday, March 29, 2018 - 12:29:41 PM
Last modification on : Saturday, June 25, 2022 - 8:59:57 PM
Long-term archiving on: : Friday, September 14, 2018 - 3:16:52 PM


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  • HAL Id : tel-01749844, version 1


Nelly Agrinier. Insuffisance cardiaque : épidémiologie, caractéristiques des patients et de leur prise en charge, et facteurs pronostiques de décès. Médecine humaine et pathologie. Université de Lorraine, 2013. Français. ⟨NNT : 2013LORR0084⟩. ⟨tel-01749844⟩



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