Étude théorique et expérimentale d'un nouveau procédé multi-colonnes continu de chromatographie préparative intégrant une étape de concentration

Abstract : This work consists in the study of Continuous Multi-Columns (MCC) processes of preparative liquid chromatography. ln particular, a new process integrating a Concentration step, named M3C, is introduced. The thesis is divided in three distinct parts. ln a bibliographic synthesis, the principal aspects of preparative chromatography in liquid phase are reviewed. A theoretical study, based on two different approaches is then presented. First, the model of the equilibrium theory, which assumes the use of an iaeal chromatographic column is considered. Then, semi-ideal models, taking into account the phenomena of dispersion are used. ln both cases, considering multicomponent Langmuir isotherms type, the performances of different MCC processes are compared in term of productivity and eluant consumption. The M3C process proved to be more efficient than the Simulated Moving Bed (SMB). The last part of this work constitutes an experimental validation of the theoretical results. Separations of optical isomers of ketoprofen are carried out on a SMB pilot and on a M3C. The experimental study shows that the productivity can be increased by a factor of at least two and that eluant consumption can be significantly reduced when a concentration step is integrated to the SMB.
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Theses
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http://docnum.univ-lorraine.fr/prive/INPL_T_2005_ABDELMOUMEN_S.pdf
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https://hal.univ-lorraine.fr/tel-01749968
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Submitted on : Thursday, March 29, 2018 - 12:34:48 PM
Last modification on : Thursday, January 31, 2019 - 1:27:50 AM

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Souhir Abdelmoumen. Étude théorique et expérimentale d'un nouveau procédé multi-colonnes continu de chromatographie préparative intégrant une étape de concentration. Alimentation et Nutrition. Institut National Polytechnique de Lorraine, 2005. Français. ⟨NNT : 2005INPL003N⟩. ⟨tel-01749968⟩

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