Designing Stimuli-Responsive Porous Silica Materials using Solid Lipid Nanoparticles (SLN) and Magneto-responsive Surfactants for Delivery of Curcumin

Abstract : This work is to prepare stimuli-responsive porous silica materials based on solid lipid nanoparticles (SLN) and magnetic surfactants. To develop this study, several surfactants systems were used to synthesize silica materials with controlled porosity via protocols described in the literature or developed in the laboratory. Different stimuli-responsive characters were introduced in porous silica materials as a function of system used: solid lipid nanoparticles (SLN) for pH-sensitive and magnetic-sensitive surfactants for magnetic silica materials. First, the materials synthesized with solid lipid nanoparticles (SLN) were used for the delivery of an anti-carcinogenic drug, curcumin. A coating method on silica surface was also used to better control the release of curcumin. Secondly, the responsiveness to the magnetic field was introduced in silica materials using the magnetic surfactants. Their self-assembly properties (i.e. micelles, vesicles) were studied and their applications in the synthesis of magnetic porous silica materials were investigated. Finally, the magnetic solid lipid nanoparticles have been prepared by combining SLN with magnetic surfactants, which have been used for the synthesis of meso-macroporous silica catalyst encapsulating iron oxide nanoparticles.
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Sanghoon Kim. Designing Stimuli-Responsive Porous Silica Materials using Solid Lipid Nanoparticles (SLN) and Magneto-responsive Surfactants for Delivery of Curcumin. Other. Université de Lorraine, 2015. English. ⟨NNT : 2015LORR0132⟩. ⟨tel-01752026⟩

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