L'anxiété trait et son lien avec l'expression des sous-unités des récepteurs (GABAA, 5-HT1A, µ-opioïdes et x1-adrénérgiques) et des marqueurs du stress oxydatif au niveau du SNC (neurones et cellules gliales) et au niveau périphérique (immunité cellulaire et humorale) : évaluation des effets de substances naturelles à potentiel cytoprotecteur

Abstract : In this study, genes expression from four central receptors (GABAA, 5-HT1A, m-opioïdes and a1-adrenergic) involved in the modulation of anxiety was assessed. The impact of anxiety on the cellular and humoral immunity and on the oxidative status at the SNC (neurons and glial cells) and peripheral (lymphocytes, granulocytes and monocytes) level was highlighted. At the same time, the effect of anxiety coupled with an anxiogenic restraint stress, on the cellular and humoral immunity was also evaluated. Indeed, the high level of anxiety induced firstly, a significant depressive effect on cellular (total lymphocytes, TCD4+ and TCD8+) and humoral (IgA and IgE) immunity, and secondly, a significant increase of the level of intracellular reactive oxygen species (ROS) of neurons and glial cells in the cerebral cortex, the cerebellum and the hippocampus and in the peripheral blood granulocytes, monocytes and lymphocytes. In the same way, the anxiety coupled to acute and chronic restraint stress provoked, a depression of some parameters of cellular (total lymphocytes, TCD4+, TCD8+ and NK) and humoral (IgA, E and G) immunity, and a stimulation of others (granulocytes and monocytes). These works thus made it possible to validate scientifically the anxiogenic character of the model of restraint stress, to establish in a valid and reproducible way the bond and the correlation between the high level of anxiety in animals and their oxidative status inductive of a cytotoxicity as well as the role of the expression of coding genes of 4 receptors in the expression of this high anxiety and of a significant oxidative status at the level of the peripheral cells of the immune system and the neurons and glial cells at the central level
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Hassan Rammal. L'anxiété trait et son lien avec l'expression des sous-unités des récepteurs (GABAA, 5-HT1A, µ-opioïdes et x1-adrénérgiques) et des marqueurs du stress oxydatif au niveau du SNC (neurones et cellules gliales) et au niveau périphérique (immunité cellulaire et humorale) : évaluation des effets de substances naturelles à potentiel cytoprotecteur. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 2008. Français. ⟨NNT : 2008METZ018S⟩. ⟨tel-01752585⟩

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