Impact environnemental des médicaments à usage humain sur le milieu récepteur : évaluation de l'exposition et des effets pour les écosystèmes d'eau douce

Abstract : A high number of pharmaceuticals are used in France and can reach the aquatic environment. This observation have contributed to a growing concern for authorities in targeting and quantifying these substances in freshwaters. Considering the high number of molecules used in France, it is necessary, prior to implement any comprehensive monitoring survey in freshwaters, to build a list of priority pharmaceuticals in terms of their risk for the aquatic environment. The work conducted here aims at proposing reliable lists of priority pharmaceuticals, based on expected environmental concentrations and biological effects on aquatic non-target organisms. Several methodologies were implemented, depending on the type of pharmaceuticals assessed and the availability of data. Finally, 300 parent molecules and 50 human metabolites were screened and scientifically sound priority lists were built. Moreover, this work allowed to draw the following conclusions : The issue of pharmaceutical mixtures and their interactions with other environmental polutants needs to be addressed. Preventing the rejection of human pharmaceuticals in the aquatic environment should be a priority. For a good management of the environmental risk of pharmaceuticals, an agreement between public health authorities, environment authorities on one hand, and pharmaceutical industries and professionals on the other hand, is necessary
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Jean-Philippe Besse. Impact environnemental des médicaments à usage humain sur le milieu récepteur : évaluation de l'exposition et des effets pour les écosystèmes d'eau douce. Sciences agricoles. Université Paul Verlaine - Metz, 2010. Français. ⟨NNT : 2010METZ023S⟩. ⟨tel-01752937⟩

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