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La réaction phosphine imide en milieu CO2 supercritique

Abstract : In the aim to propose a substitution process to the use of phosgene for the production of isocyanates and their derivatives, we devoted this work to the study of the phosphine imide reaction in supercritical CO2. In this context, we have chosen a standard reaction and investigated the influence of operational parameters on the kinetic of this reaction in CO2 using a high pressure 100 ml reactor. Analyses of the samples were performed using high performance liquid chromatography. These observations permits to develop a first order kinetic model, and we have compared the results obtained using this model with the observations we realized in a high pressure 1l reactor. We have compared the kinetics obtained in CO2 with those observed in dimethylformamide. We have also studied in dimethylformamide and CO2 the influence of the "catalyst" which permits to obtain isocyanates. We've finally performed the synthesis of a compound of pharmaceutical interest, which increase the bioavailability of Busulfan, in CO2 using phosphine imide reaction and we have followed the kinetic of this reaction
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https://hal.univ-lorraine.fr/tel-01753003
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Alexandre Scondo. La réaction phosphine imide en milieu CO2 supercritique. Autre. Institut National Polytechnique de Lorraine, 2008. Français. ⟨NNT : 2008INPL077N⟩. ⟨tel-01753003⟩

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