Conception et développement de systèmes d'aide à la compréhension de données biologiques et moléculaires; application à la modélisation des récepteurs couplés aux protéines G

Abstract : This manuscript describes , (i) the work carried on in the context of the Viseur project, a set of tool and bioinformatic ressources dedicated to helping G Protein Coupled Receptors modeling (GPCRs); (ii) an illustration of the reuse of computational chemistry legacy software for building a conformational search program with the adaptative simulated annealing optirnization algorithm (use of object-oriented technics, generic programming, and mixed-language programming) ; (iii) An in-depth reflexion about the design and realization of tools dedicated to assist the biologist, biochemist, and modeling chemist during his research work that is built upon the real examples given in (i) and (ii) , and the acknowledgment of recent technological advances (internet and Intranet networks , software component technology, CORBA, etc). Point (iii) is concluded by the description of the architecture of a software prototype, realized according to this reflexion.
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Fabien Campagne. Conception et développement de systèmes d'aide à la compréhension de données biologiques et moléculaires; application à la modélisation des récepteurs couplés aux protéines G. Autre. Université Henri Poincaré - Nancy 1, 1998. Français. ⟨NNT : 1998NAN10101⟩. ⟨tel-01754347⟩

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