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Modulation de TREM-1 au cours du l'infarctus du myocarde

Abstract : Despite improvements in therapeutic management of acute myocardial infarction, the prevalence of this deadly condition remains high. Intensive research has raised the critical and ambivalent role of immune response after myocardial infarction. Optimal healing requires an inflammatory reaction for debris removal and scar formation, but unrestrained immune response leads to infarct expansion and maladaptive remodeling. TREM-1 is an immune-receptor that acts as an amplifier of the innate immune response. Blockade of TREM-1 activation by a short inhibitory peptide, LR12, protects from inflammatory hyper-responsiveness. Through various experimental models, we show that TREM-1 modulation improves outcome after myocardial infarction (infarct size, heart function, ventricular remodeling), with significant impact on neutrophils recruitment within the myocardium. TREM-1 could constitute a new therapeutic target in the fight against myocardial infarction and post-ischemic heart failure
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Submitted on : Friday, March 30, 2018 - 9:51:14 AM
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Jérémie Lemarié. Modulation de TREM-1 au cours du l'infarctus du myocarde. Médecine humaine et pathologie. Université de Lorraine, 2016. Français. ⟨NNT : 2016LORR0005⟩. ⟨tel-01754496⟩



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