Régulations des systèmes nerveux central et immunitaire en condition de stress : rôle de la corticotropin-releasing hormone et de ses récepteurs

Abstract : In stress conditions, the Hypothalamo-Pituitary-Adrenal (HPA) axis activation leads to an overproduction of glucocorticoïds (such as corticosterone in rodent) by adrenal glands and this activation is well characterized. However, various questions remain about the precise role of corticotropin-releasing hormone (CRH), which is at the beginning of the HPA activation. Indeed, CRH receptors are presents both in central nervous system (CNS), especially in cerebellum, and in immune system (IS). This suggest a possible direct action of this hormone on both system. In this project, we studied the regulations on CNS and IS in stress conditions and more particularly the CRH role and these receptors in these regulations. After chronic corticsterone injections, to mimic a stress, we observed a locomotor alteration which seems to be inverted when CRH-R1 were inhibited with an antagonist. These first results show an possible CRH role in locomotor regulation in cerebellum under stress condition. In parallel, others in vitro studies performed on murine splenocytes stimulated with CRH showed a B lymphocyte (LB) viability decrease. Furthermore, we are the first to characterise the CRH receptors on murine LB. This work show the CRH importance in CNS and IS regulations under stress conditions and its role in interactions between the two systems
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Guillaume Harlé. Régulations des systèmes nerveux central et immunitaire en condition de stress : rôle de la corticotropin-releasing hormone et de ses récepteurs. Médecine humaine et pathologie. Université de Lorraine, 2016. Français. ⟨NNT : 2016LORR0126⟩. ⟨tel-01754691⟩

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