Etude pharmacologique d'une rutacée de la pharmacopée traditionnelle africaine, Xanthoxylum xanthoxyloïdes Waterm

Abstract : X. Xanthoxyloides has been selected among several african plants used in drinkings producing transes in vaudou practices : our prupose was to confirm the supposed psychotropic effect of these extracts. After a botanical study of the plant, we have realised a chemical study which has shown a great richness in alkaloids. A bibliographical study has revealed that X. xanthoxyloides is used by african tradipraticians to cure varieted affections : diverse pains, intestinal, dermatological desorders, ferver and falcemy. Pharmacological studies already published, have confirmed some of those properties, like anti-falcemiant properties. So we have undertaken to check our hypothesis of a psychotropic effect of x. xanthoxyloides, and then to confirm the traditional prescription of the extracts again pain. X. xanthoxyloides has shown a potentiating effect on hypnotic action of the barbiturates. We have precised the site of this interaction, which is central. This has oriented our work towards the research of behavioural effects. The extracts have sedative effects at high doses, and anxiolytic effects at low doses. They have no neuroleptic effects, but present a slight anti-depressing ffect. They have no anti-convulsing effects butopentiate the stereotypies induced by amphetamine. These results have permissed to us to propose a pharmacological profile, with caracteristics a minor tranquilliser. The anagesiceffects of the extracts have been confirmed/ The site of action would be the same as morphinic compounds, central analgesics. X xanthoxyloides also, has anti-pyretic properties. So we have confirmed traditional prescriptions of x. xantholoides as an analgesic, and we have justified its use in induction of transes because of sedative and anxiolytic effects
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Isabelle Bertrand. Etude pharmacologique d'une rutacée de la pharmacopée traditionnelle africaine, Xanthoxylum xanthoxyloïdes Waterm. Biologie végétale. Université Paul Verlaine - Metz, 1988. Français. ⟨NNT : 1988METZ023S⟩. ⟨tel-01775551⟩

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