Toxicologie comparée de deux classes d'insecticides : un organophosphore le fénitrothion et un pyréthrinoïde "la cyperméthrine" chez l'abeille mellifère (Apis mellifera mellifera. L.) : études au laboratoire et sur le terrain

Abstract : The aim of this thesis is to study comparatively the toxicity of two insecticides, cypermethrin and fenitrothion on honeybees (Apis mellifera mellifera. L). Following a general bibliography synthesis, the first chapter presents a comparative evaluation of the two insecticides, including the use of a new algebraic concepts from the Hill equation as an alternative to LD50. This new toxicological parameters allows a strong evaluation of the toxicity of any substance, and can be used to compare and to classify many compounds with rspect to their relative toxicity, while completely avoiding the problem of arbitrary choices in the calculation of LD50. In concordance to theses news parameters, cypermethrin seems to be more toxic than fenitrothion. The second chapter shows the impact of cypermethrin and fenitrothion on the haemolymph carbohydrates (glucose and trehalose) where these two insecticides induced a serious damage. Both (Na+, K+)ATPase and Acétylcholinesterase were also affected by these two insecticides, however cypermethrin did not induce any significant inhibition of acetylcholinesterase comparatively to the fenitrothion's action. The last chapter deals with field studies showing many perturbations occuring in treated hives in contrast to control ones on : foraging activity, hive'smortality, bees behaviour, brood areas, glucosemia and threhalosemia and ATPase of the colonies fed continuousely by cypermethrin at subletal doses
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Najib Bendahou. Toxicologie comparée de deux classes d'insecticides : un organophosphore le fénitrothion et un pyréthrinoïde "la cyperméthrine" chez l'abeille mellifère (Apis mellifera mellifera. L.) : études au laboratoire et sur le terrain. Sciences agricoles. Université Paul Verlaine - Metz, 1994. Français. ⟨NNT : 1994METZ049S⟩. ⟨tel-01776800⟩

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