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Effet de la fluoxétine sur certains composés sérotoninergiques et catécholaminergiques, dosés par CLHP, lors d'une étude clinique chez des patients mélancoliques et d'une dépression provoquée chez le rat

Abstract : The aim of the present work was to study at first the correlation between MHPG (3-methoxy-4-hydroxyphenylglycol) levels and an inhibitor of serotonin uptake in 32 patients with melancholia treated by fluoxetine at 20 mg/day. The analytical data of serotonin in platelets, free, conjugated (sulfate and glucuronide) and total MHPG in plasma and urine, fluxetine and norfluoxetine in plsma were compared to the clinical results as measured by HDS/MES scores in order to test the hypothesis of noradrenergic or serotoninergic depressive subtypes. In a next study, we have explored in parallel to these clinical observations, the consequences of a fluoxetine intraperitoneal injection, at various doses, in adults, upon the concentrations of serotonin, 5-HIAA, fluoxetine and norfluoxetine in the brain and the concentrations of serotonin, fluoxetine and norfluoxetine in blood. The same experiment will be performed after an intraperitoneal injection of norfluoxetine. In the third assay, we studied the fluoxetine effects, in curative treatment, in the depression model of inavoidable aversive light stimulus in rats. The same measures will be effect than those in the previous study
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https://hal.univ-lorraine.fr/tel-01777176
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Roland Bourdeaux. Effet de la fluoxétine sur certains composés sérotoninergiques et catécholaminergiques, dosés par CLHP, lors d'une étude clinique chez des patients mélancoliques et d'une dépression provoquée chez le rat. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 1996. Français. ⟨NNT : 1996METZ055S⟩. ⟨tel-01777176⟩

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