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Potentiel antimicrobien de principes actifs d’origine naturelle

Abstract : The development of a natural bioactive compounds could be a mean of developing new alternatives to antibiotics. Tea tree essential oil is known for its numerous properties and its broad-spectrum antimicrobial activity, but also for its toxicity and its high content in allergens due to its composition in monoterpenes. In this study, we search for new natural compounds extracted from tea tree essential oil, which has equivalent antimicrobial activity but less toxicity and a reduced allergenic activity. Two bioactive compounds have been thus studied. Titroléane™ - a fraction of tea tree essential oil enriched in monoterpene alcohols but with a very low rate of monoterpenes - has shown microbiological activities similar to tea tree essential oil. As for Synterpicine™, it is only composed of the two main molecules of the essential oil, and presents a reduced cytotoxicity. The characterization of the compounds’ efficacy was carried out with different in vitro study methods, to define their inhibitory and bactericide activity, on planktonic and biofilm bacteria. Finally, the research of new active molecules within the active compounds, was pursued thanks to a high performance thin layer chromatography, paired up with a microbiological study by bioautography. This study has highlighted the antimicrobial activity of two new natural active extracts which can be valorised on different markets- especially human health
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Submitted on : Friday, November 16, 2018 - 12:15:18 PM
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  • HAL Id : tel-01924849, version 1



Bianca Johansen. Potentiel antimicrobien de principes actifs d’origine naturelle. Phytopathologie et phytopharmacie. Université de Lorraine, 2017. Français. ⟨NNT : 2017LORR0242⟩. ⟨tel-01924849⟩



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