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Anomalies fonctionnelles rétiniennes dans les troubles neuropsychiatriques et leurs liens avec les dysfonctionnements cérébraux

Abstract : One of major obstacles in neuroscience and psychiatry research is the difficulty of directly accessing the brain function to understand the biological mechanisms underlying brain dysfunctions in psychiatric and addictive disorders. As an anatomical and developmental extension of the central nervous system, the retina could afford to offer an indirect access to brain neurological functions. Investigating the retinal function provides the unique opportunity to study in an objective way a complex neuronal network which shares similar properties with the brain. Our team was initially interested in the study of retinal function in regular cannabis users in which we showed dysfunctions in several retinal stages and observed with electrophysiological measurements based on electroretinogram. These results could help to clarify the modulations of cerebral synaptic transmission induced by regular use of cannabis. Thus, we hypothesize that changes in retinal function may be related to specific changes in brain neurotransmission in neuropsychiatric disorders. Currently, in order to validate these hypotheses, we evaluate retinal function in several neuropsychiatric and addictive disorders such as major depressive disorder, schizophrenia and regular use of tobacco, alcohol and cannabis. These measures could eventually provide models for understanding neurotransmission anomalies and provide functional physiological markers in the field of neuropsychiatric and addictive disorders.
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https://hal.univ-lorraine.fr/tel-02355913
Contributor : Thomas Schwitzer <>
Submitted on : Friday, November 8, 2019 - 2:42:23 PM
Last modification on : Friday, October 23, 2020 - 4:48:46 PM
Long-term archiving on: : Monday, February 10, 2020 - 3:52:09 AM

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Thomas Schwitzer. Anomalies fonctionnelles rétiniennes dans les troubles neuropsychiatriques et leurs liens avec les dysfonctionnements cérébraux. Neurosciences [q-bio.NC]. Université de Lorraine, 2019. ⟨tel-02355913⟩

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