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Theses

Effets de stress associés aux vols spatiaux sur le système du complément et les cellules dendritiques

Abstract : During spaceflights, astronauts encounter numerous stresses leading to immune system impairment. Given the scarcity of space missions, simulation models are used on Earth to study the effects of spaceflight-associated stresses on the immune system. The aim of this thesis was to study the effects of spaceflight-associated stresses on the complement system and on dendritic cells (DC). First, we studied the effects of individual or combined spaceflight-associated stresses on the C3 molecule expression in amphibians and mice. We showed that some of these stresses such as microgravity increased the C3 complement expression in P. waltl larvae but no variation were found in mice subjected to simulated microgravity (hindlimb unloading model). We also studied the effects of simulated microgravity by RPM on murine DC phenotype and function. We showed that RPM exposure impaired both DC actin cytoskeleton and survival. Moreover, DC exposed to simulated microgravity showed an immature phenotype characterized by a decrease of co-stimulation molecule expression and pro-inflammatory cytokines secretion, which are essentials for DC functions. However, these numerous alterations did not affect antigen presentation to T cells. Taken together, these results highlight the significant effects of spaceflight-associated stresses on the immune system. Studying microgravity will allow to better understand its effects on health and to develop adapted countermeasures.
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Theses
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http://docnum.univ-lorraine.fr/ulprive/DDOC_T_2019_0198_JEANDEL.pdf
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https://hal.univ-lorraine.fr/tel-02529109
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Submitted on : Thursday, April 2, 2020 - 10:21:48 AM
Last modification on : Tuesday, October 13, 2020 - 10:46:05 AM

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  • HAL Id : tel-02529109, version 1

Citation

Jérémy Jeandel. Effets de stress associés aux vols spatiaux sur le système du complément et les cellules dendritiques. Immunologie. Université de Lorraine, 2019. Français. ⟨NNT : 2019LORR0198⟩. ⟨tel-02529109⟩

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