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S-nitrosoglutathion et perméabilité intestinale : de la mise en place d’un modèle de chambre de Ussing à l’étude de l’impact de ce donneur de monoxyde d’azote sur la barrière intestinale

Abstract : Nitric oxide is known for its many actions to maintain intestinal barrier homeostasis, regulating mucus secretion, oxidative stress, immune system… S-nitrosoglutathione (GSNO), a nitric oxide donor naturally produced by the organism, has shown a beneficial effect on the intestinal barrier reinforcement. Nowadays, challenge is to understand the mechanisms inherent to this observation. For that, a Ussing chamber study was performed. After the model validation, by following permeability markers, histological studies, and cell junction proteins expression study, the GSNO metabolism administered in the intestinal lumen was explored. Also, GSNO effect on the intestinal barrier permeability was evaluated. Results allow today to consider GSNO as an interesting and promising drug candidate, in the context of intestinal, cardiovascular or cerebral pathologies.
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https://hal.univ-lorraine.fr/tel-02960438
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Submitted on : Wednesday, October 7, 2020 - 4:52:43 PM
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  • HAL Id : tel-02960438, version 1

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Romain Schmitt. S-nitrosoglutathion et perméabilité intestinale : de la mise en place d’un modèle de chambre de Ussing à l’étude de l’impact de ce donneur de monoxyde d’azote sur la barrière intestinale. Sciences du Vivant [q-bio]. Université de Lorraine, 2019. Français. ⟨NNT : 2019LORR0342⟩. ⟨tel-02960438⟩

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