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Distribution et élimination de la chlordécone chez les animaux d’élevage – modélisation des processus

Abstract : The use of chlordecone (CLD), an organochlorine pesticide used in the French West Indies banana fields between 1972 and 1993, resulted in a long-term pollution of agricultural areas. Animals may be exposed to CLD by ingesting contaminated food or environmental matrices (soil, water or plants). This PhD project is integrated in the objective of securing animal sectors against CLD risk.The aims of this thesis are (1) to provide knowledge on distribution and elimination mechanisms of CLD in farm animals and (2) to develop decision support tools to assist local animal sectors. To this end, in vivo experiments were performed in adult ewes and growing pigs. In pigs, two experiments consisting of monitoring serum and fecal elimination kinetics following a single intravenous administration of CLD or CLDOH (chlordecol) were performed. Non-compartmental and compartmental approaches were used to estimate toxicokinetic parameters of CLD and its metabolites from serum kinetics. Faecal kinetics were used to characterize metabolism of CLD and to quantify its faecal excretion. In ewes, these toxicokinetic data were already available in literature, so the objective was to complete them by characterizing CLD distribution. An experiment involving sequentially slaughters during contamination and decontamination phases allowed to characterize the distribution dynamics of CLD. Correlations between concentrations in tissues were established and CLD half-lives in tissues were calculated. The monitoring of fecal kinetics provided additional knowledge on CLD excretion. All toxicokinetic results obtained in ewes were used to develop a physiologically based pharmacokinetic (PBPK) model to predict CLD concentrations in various tissues. This model will be used to develop decision support tools to assist animal sectors in CLD contaminated areas. An in vivo study is being considered in pigs to characterize the dynamics of CLD tissue distribution and thus be able to develop similar tools to those developed in ewes.
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Submitted on : Monday, July 12, 2021 - 8:46:11 PM
Last modification on : Wednesday, July 14, 2021 - 3:40:01 AM

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  • HAL Id : tel-03284812, version 1

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Aurore Fourcot. Distribution et élimination de la chlordécone chez les animaux d’élevage – modélisation des processus. Toxicologie. Université de Lorraine, 2020. Français. ⟨NNT : 2020LORR0260⟩. ⟨tel-03284812⟩

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